The study was performed at the University of Washington and Seattle Cancer Care Alliance in Seattle, WA.
The review initiated with 592 patients who were recently diagnosed with breast cancer and underwent staging with preoperative breast MRI. The analysis set was comprised of 570 patients, whose biopsy rates, positive predictive values (PPVs) of biopsy, and overall cancer yields were calculated and compared using the chi-square test across patient age, breast density, index tumor type, receptor status and lymph node status.
"Our data add to the growing body of literature that documents breast MRI's ability to detect otherwise occult additional disease in patients who have been newly diagnosed with breast cancer," said Robert Gutierrez, MD, lead author of the study.
"We found that use of preoperative breast MRI in newly diagnosed cancer patients resulted in an added cancer yield of 12%.This is much higher than the added cancer yield of .08 to 6.7% seen with high risk screening breast MRI, a more widely accepted indication for breast MRI, " said Gutierrez.
"A major strength of our study is our sample size of 570 patients, which is larger than most prior investigations. Additionally, unlike the majority of preoperative breast MRI studies, our patient population is more representative of a broad diagnostic population, which is a result of the practice pattern at our site of routinely performing preoperative breast MRI in newly diagnosed breast cancer patients, "he said.
This study appears in the January 2011 issue of the American Journal of Roentgenology.
Keri Sperry | EurekAlert!
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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