Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Prenatal Phthalate Exposures and Anogenital Distance in Swedish Boys

29.10.2014

The first study to examine prenatal exposure to the phthalate DiNP finds it is associated with a shorter anogenital distance (AGD) in Swedish boys at the age of 21 months.

These findings raise concern since animal research has linked DiNP exposure to a shorter AGD, and studies on humans have related shorter AGD to male genital birth defects as well as impaired reproductive function in adult males, and the levels of DiNP metabolites in humans are increasing globally.


Carl-Gustaf Bornehag, professor in Public Health Sciences at Karlstad University

Karlstad University

Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and found in a large number of commonly used consumer products. Due to reported health risk, di-isononyl phthalate (DiNP) has been introduced as a replacement for diethyl hexyl phthalate (DEHP) as a plasticizer in soft PVC. This raises concerns since animal data suggest that DiNP may have anti-androgenic properties similar to DEHP.

In addition, biomonitoring data show that human DiNP metabolite levels are rapidly increasing globally. The anogenital distance (AGD) - the distance from the anus to the genitals - is a marker that has been used in animal studies to assess reproductive toxicity. While several studies have examined phthalates such as DBP, DEHP and AGD in humans, none has included DiNP.

The purpose of the current study have been to examine the relationship between 1st trimester urinary metabolite concentrations (week 9-11) of DEP, DBP, DEHP, BBzP as well as DiNP in relation to AGD in 196 Swedish boys at 21 months of age. Analyzes of the mothers urine, identified all phthalate metabolites in all samples. Anogenital distance was measured by two pediatric nurses at County Council of Värmland, Sweden. The measured phthalate levels and AGD were comparable with data from two pregnancy cohort studies in USA.

Most of the phthalate metabolites were associated with a shorter AGD, however, not all associations reached significance. The strongest and significant associations were found between a shorter AGD and DiNP metabolites.

These findings call into question the safety of the recent substitution of DiNP for DEHP in soft PVC, particularly since a shorter male AGD has been shown to be related to male genital birth defects in children (such as hypospadias and undescended testis) and impaired reproductive function in adult males (such as decreased fertility, impaired semen quality and lower serum testosterone levels) and the fact that human levels of DiNP are rapidly increasing globally, says Carl-Gustaf Bornehag, professor in Public Health Sciences at Karlstad University and responsible for the current study.

Bornehag, C.G., Carlstedt, F., Jönsson, B.A.G., Bodin, A., Jonsson, C., Janson, S., Swan, S.
Prenatal Phthalate Exposures and Anogenital Distance in Swedish Boys. Environmental Health Perspective 2014; DOI:10.1289/ehp.1408163

Carl-Gustaf Bornehag, PI of the SELMA study and the current study
Public Health Sciences, Karlstad University and SP Technical Research Institute of Sweden
Tel; +46 54 700 2540; Cell: +46 70 586 6565; Email; carl-gustaf.bornehag@kau.se

Pressofficer Carina Olsson; +46 (0)70-6015464 carina.olsson@kau.se

Weitere Informationen:

http://ehp.niehs.nih.gov/1408163/ article in Environmental Health Perspective

Carina Olsson | idw - Informationsdienst Wissenschaft

More articles from Studies and Analyses:

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Disarray in the brain
18.12.2017 | Universität zu Lübeck

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

White graphene makes ceramics multifunctional

16.01.2018 | Materials Sciences

Breaking bad metals with neutrons

16.01.2018 | Materials Sciences

ISFH-CalTeC is “designated test centre” for the confirmation of solar cell world records

16.01.2018 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>