This study, led by Masayo Takahashi M.D., Ph. D. of the Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, and conducted in collaboration with the Institute for Biomedical Research and Innovation with support from the Kobe City Medical Center General Hospital, has been approved to proceed following review by the Ministry of Health, Labour and Welfare and is scheduled to open patient recruitment on August 1, 2013.
Age-related macular degeneration is the most common cause of visual impairment in the elderly, and affects up to 1% of people over 50 years of age in Japan. Wet-type AMD is characterized by progressive damage to the retinal pigment epithelium, a protective layer of non-neural cells located adjacent to the photoreceptors at the back of the eye, due to leakage caused by neovascularization.
Currently available drug treatments for this disease focus on inhibiting neovascularization, but do not repair damage that may have already occurred prior to administration. A number of previous studies have tested the use of RPE cells from various sources, such as fetal tissue or unaffected parts of the RPE, for transplantation but have been complicated by problems of immune rejection or the need for invasive harvesting procedures.
The protocol for Takahashi’s new pilot study involves the establishment of autologous iPSCs from each of the research participants, which will then be differentiated into RPE using a novel technology that allows these epithelial cells to be transplanted in monolayer cell sheets without the use of synthetic scaffolds or matrices. The cell sheets will be shaped into 1.3 × 3 mm grafts and transplanted into the affected site of a single eye, following excision of the damaged RPE and neovascular tissues.Transplant sites will be monitored closely for functional integration
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About the Center for Developmental Biology
The RIKEN Center for Developmental Biology (CDB) was launched in April 2000 to advance research in the fields of animal development and regeneration and contribute to areas of clinical medicine that can benefit from such research. The CDB is dedicated to developing a better understanding of fundamental processes of animal development at the molecular and cell biological level, the more complex phenomena involved in organogenesis as well as the biology of stem cells and regeneration. By elucidating these processes researchers working at CDB hope to improve the effectiveness of regenerative medicine, for the benefit of society.
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