Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Physical Frailty May be Linked to Alzheimer’s Disease

12.08.2008
Physical frailty, which is common in older persons, may be related to Alzheimer’s disease pathology, according to a study published in the August 12, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology.

For the study, researchers examined the brains of 165 people who had been participants in a larger community study of chronic diseases of aging.

While participants were alive, physical frailty measurements were taken yearly including grip strength, time to walk eight feet, body composition and tiredness. After death, the brains of these participants were checked for the plaques and tangles that are signs of Alzheimer’s disease pathology.

Of the participants in the study, 36 percent of the group had dementia, or showed signs of memory loss. “Interestingly, Alzheimer’s disease pathology was associated with physical frailty in older persons both with and without dementia,” said study author Aron S. Buchman, MD, with Rush University Medical Center in Chicago and member of the American Academy of Neurology.

... more about:
»Alzheimer »Frailty »body composition »dementia

“The level of frailty was approximately two times higher in a person with a high level of AD pathology compared with a person with a low level of AD pathology,” said Buchman. The results remained the same regardless of whether a person had a history of other diseases and regardless of their level of physical activity.

A previous study of the same group of participants while they were alive suggested that older people who are physically frail with no cognitive impairment appear to be at higher risk of developing Alzheimer’s disease as compared to those who were less frail. “Together both of these studies suggest that frailty can be an early indicator of Alzheimer’s disease pathology and may appear before memory loss.”

“These findings raise the possibility that Alzheimer’s disease may contribute to frailty or that frailty and Alzheimer’s disease share a common cause. We theorize that the accumulation of these plaques and tangles in the brain could affect the areas of the brain responsible for motor skills and simple movements years before the development of dementia,” Buchman said.

Studies show that about seven percent of people over age 65 are considered frail; that number jumps to 45 percent after age 85.

The study was supported by the National Institute on Aging, the Illinois Department of Public Health and the Robert C. Borwell Endowment Fund.

The American Academy of Neurology, an association of more than 21,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as epilepsy, dystonia, migraine, Huntington’s disease, and dementia. For more information about the American Academy of Neurology, visit www.aan.com.

Rachel Seroka | American Academy of Neurology
Further information:
http://www.neurology.org/future.shtml
http://www.aan.com

Further reports about: Alzheimer Frailty body composition dementia

More articles from Studies and Analyses:

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>