For the study, researchers examined the brains of 165 people who had been participants in a larger community study of chronic diseases of aging.
While participants were alive, physical frailty measurements were taken yearly including grip strength, time to walk eight feet, body composition and tiredness. After death, the brains of these participants were checked for the plaques and tangles that are signs of Alzheimer’s disease pathology.
Of the participants in the study, 36 percent of the group had dementia, or showed signs of memory loss. “Interestingly, Alzheimer’s disease pathology was associated with physical frailty in older persons both with and without dementia,” said study author Aron S. Buchman, MD, with Rush University Medical Center in Chicago and member of the American Academy of Neurology.
“The level of frailty was approximately two times higher in a person with a high level of AD pathology compared with a person with a low level of AD pathology,” said Buchman. The results remained the same regardless of whether a person had a history of other diseases and regardless of their level of physical activity.
A previous study of the same group of participants while they were alive suggested that older people who are physically frail with no cognitive impairment appear to be at higher risk of developing Alzheimer’s disease as compared to those who were less frail. “Together both of these studies suggest that frailty can be an early indicator of Alzheimer’s disease pathology and may appear before memory loss.”
“These findings raise the possibility that Alzheimer’s disease may contribute to frailty or that frailty and Alzheimer’s disease share a common cause. We theorize that the accumulation of these plaques and tangles in the brain could affect the areas of the brain responsible for motor skills and simple movements years before the development of dementia,” Buchman said.
Studies show that about seven percent of people over age 65 are considered frail; that number jumps to 45 percent after age 85.
The study was supported by the National Institute on Aging, the Illinois Department of Public Health and the Robert C. Borwell Endowment Fund.
The American Academy of Neurology, an association of more than 21,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as epilepsy, dystonia, migraine, Huntington’s disease, and dementia. For more information about the American Academy of Neurology, visit www.aan.com.
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Earth Sciences
19.01.2017 | Life Sciences
19.01.2017 | Physics and Astronomy