“Misunderstanding social situations and interactions are core deficits in schizophrenia,” said Sohee Park, Gertrude Conaway Professor of Psychology and one of the co-authors on this study. “Our findings may help explain the origins of some of the delusions involving perception and thoughts experienced by those with schizophrenia.”
In findings published in the journal PLoS ONE, the researchers found that a particular brain area, the posterior superior temporal sulcus or STS, appears to be implicated in this deficit.
“Using brain imaging together with perceptual testing, we found that a brain area in a neural network involved in perception of social stimuli responds abnormally in individuals with schizophrenia,” said Randolph Blake, Centennial Professor of Psychology and co-author. “We found this brain area fails to distinguish genuine biological motion from highly distorted versions of that motion.”
The study’s lead author, Jejoong Kim, completed the experiments as part of his dissertation under the supervision of Park and Blake in Vanderbilt’s Department of Psychology. Kim is now conducting research in the Department of Brain and Cognitive Sciences at Seoul National University in Korea, where Blake is currently a visiting professor.
“We have found… that people with schizophrenia tend to ‘see’ living things in randomness and this subjective experience is correlated with an increased activity in the (posterior) STS,” the authors wrote. “In the case of biological motion perception, these self-generated, false impressions of meaning can have negative social consequences, in that schizophrenia patients may misconstrue the actions or intentions of other people.”
In their experiments, the researchers compared the performance of people with schizophrenia to that of healthy controls on two visual tasks. One task involved deciding whether or not an animated series of lights depicted the movements of an actor’s body. The second task entailed judging subtle differences in the actions depicted by two similar animations viewed side by side. On both tasks, people with schizophrenia performed less well than the healthy controls.
The fMRI results showed strong activation of the posterior portion of the STS in the healthy controls when they were shown biological motion. In the individuals with schizophrenia, STS activity remained relatively constant and high regardless of what was presented to them.
Analysis of the brain activity of the schizophrenia patients also showed high STS activity on trials where they reported seeing biological motion, regardless of whether the stimulus itself was biological or not.
For reasons yet to be discovered, area STS in schizophrenia patients fails to differentiate normal human activity from non-human motion, leading Kim and colleagues to surmise that this abnormal brain activation contributes to the patients’ difficulties reading social cues portrayed by the actions of others.
The research was funded with support from the Brain and Behavior Research Foundation (formerly the National Alliance for Research on Schizophrenia and Depression) and the National Research Foundation of Korea in the Korean Ministry of Education, Science and Technology.Contact:
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland
Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Health and Medicine
29.03.2017 | Earth Sciences
29.03.2017 | Trade Fair News