Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Why people with schizophrenia may have trouble reading social cues

25.05.2011
Understanding the actions of other people can be difficult for those with schizophrenia. Vanderbilt University researchers have discovered that impairments in a brain area involved in perception of social stimuli may be partly responsible for this difficulty.

“Misunderstanding social situations and interactions are core deficits in schizophrenia,” said Sohee Park, Gertrude Conaway Professor of Psychology and one of the co-authors on this study. “Our findings may help explain the origins of some of the delusions involving perception and thoughts experienced by those with schizophrenia.”

In findings published in the journal PLoS ONE, the researchers found that a particular brain area, the posterior superior temporal sulcus or STS, appears to be implicated in this deficit.

“Using brain imaging together with perceptual testing, we found that a brain area in a neural network involved in perception of social stimuli responds abnormally in individuals with schizophrenia,” said Randolph Blake, Centennial Professor of Psychology and co-author. “We found this brain area fails to distinguish genuine biological motion from highly distorted versions of that motion.”

The study’s lead author, Jejoong Kim, completed the experiments as part of his dissertation under the supervision of Park and Blake in Vanderbilt’s Department of Psychology. Kim is now conducting research in the Department of Brain and Cognitive Sciences at Seoul National University in Korea, where Blake is currently a visiting professor.

“We have found… that people with schizophrenia tend to ‘see’ living things in randomness and this subjective experience is correlated with an increased activity in the (posterior) STS,” the authors wrote. “In the case of biological motion perception, these self-generated, false impressions of meaning can have negative social consequences, in that schizophrenia patients may misconstrue the actions or intentions of other people.”

In their experiments, the researchers compared the performance of people with schizophrenia to that of healthy controls on two visual tasks. One task involved deciding whether or not an animated series of lights depicted the movements of an actor’s body. The second task entailed judging subtle differences in the actions depicted by two similar animations viewed side by side. On both tasks, people with schizophrenia performed less well than the healthy controls.

fMRI used to i.d. brain area
Next, the researchers measured brain activity using functional magnetic resonance imaging (fMRI) while the subjects—healthy controls and schizophrenia patients—performed a version of the side-by-side task. Once again, the individuals with schizophrenia performed worse on the task. The researchers were then able to correlate those performance deficits with the brain activity in each person.

The fMRI results showed strong activation of the posterior portion of the STS in the healthy controls when they were shown biological motion. In the individuals with schizophrenia, STS activity remained relatively constant and high regardless of what was presented to them.

Analysis of the brain activity of the schizophrenia patients also showed high STS activity on trials where they reported seeing biological motion, regardless of whether the stimulus itself was biological or not.

For reasons yet to be discovered, area STS in schizophrenia patients fails to differentiate normal human activity from non-human motion, leading Kim and colleagues to surmise that this abnormal brain activation contributes to the patients’ difficulties reading social cues portrayed by the actions of others.

The research was funded with support from the Brain and Behavior Research Foundation (formerly the National Alliance for Research on Schizophrenia and Depression) and the National Research Foundation of Korea in the Korean Ministry of Education, Science and Technology.

Contact:
Melanie Moran, (615) 322-NEWS
melanie.moran@vanderbilt.edu

Melanie Moran | EurekAlert!
Further information:
http://www.vanderbilt.edu
http://www.youtube.com/watch?v=VzqeUZ-SccM
http://www.youtube.com/watch?v=_qKY-6oeYDA

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>