Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pediatric study finds alternatives for radiation of low-grade brain tumors

07.10.2008
Chemotherapy may help delay cranial radiation and minimize damaging side effects

A multi-institutional study led by researchers at The University of Texas M. D. Anderson Cancer Center has found that using chemotherapy alone and delaying or avoiding cranial radiation altogether can be effective in treating pediatric patients with unresectable or progressive low-grade glioma. The study was presented Sunday at the 40th annual International Society of Pediatric Oncology Meeting in Berlin, Germany.

Low-grade glioma is the most common brain tumor in children. If eligible for surgery, overall survival rate for these children is 95 percent. However, for patients with tumors in locations that prevent surgical removal or whose tumor is progressive after surgery, prognosis is worse.

A majority of pediatric oncologists use cranial radiation to treat patients with unresectable or progressive brain tumors. Although radiation is often effective, the long-term effects such as mental impairment, hormonal deficiencies and increased rate of stroke late in life can be detrimental to young patients - causing some physicians and families to decide against treatment.

"This is the first large, multi-institutional study to investigate using chemotherapy as an alternative to cranial radiation," says Joann Ater, M.D., professor of pediatrics at the Children's Cancer Hospital at M. D. Anderson. "The results have confirmed the ability of chemotherapy to control the disease."

Ater is principal investigator for the Children's Oncology Group (COG) study and developed the Phase III trial, which compared two different chemotherapy regimens across three different patient groups. Smaller pilot studies have shown a carboplatin and vincristine (CV) regimen to be effective against low-grade glioma. However, the COG trial with 401 patients enrolled, showed that a thioguanine, procarbazine, lomustine and vincristine (TPCV) regimen was more effective than the CV regimen and resulted in a five-year event-free survival rate of nearly 50 percent.

Patients under 5 years old averaged 2.2 years before the disease progressed on the CV regimen, while patients between 5 to 10 years old, averaged 5.3 years before disease progression. Patients on the TPCV regimen fared better, with those 5 to 10 years old averaging more than eight years without disease progression. The trial also studied chemotherapy for neurofibromatosis patients who had low-grade gliomas. This patient population had the best response to chemotherapy among the three groups.

"If we can delay radiation, then we allow more time for our youngest patients to develop physically, which could decrease some of the long-term effects from treatment," Ater says. "This trial at least gives parents more information and alternative options when making decisions about their child's treatment."

Sara Farris | EurekAlert!
Further information:
http://www.mdanderson.org
http://www.mdanderson.org/children

More articles from Studies and Analyses:

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>