Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pediatric study finds alternatives for radiation of low-grade brain tumors

07.10.2008
Chemotherapy may help delay cranial radiation and minimize damaging side effects

A multi-institutional study led by researchers at The University of Texas M. D. Anderson Cancer Center has found that using chemotherapy alone and delaying or avoiding cranial radiation altogether can be effective in treating pediatric patients with unresectable or progressive low-grade glioma. The study was presented Sunday at the 40th annual International Society of Pediatric Oncology Meeting in Berlin, Germany.

Low-grade glioma is the most common brain tumor in children. If eligible for surgery, overall survival rate for these children is 95 percent. However, for patients with tumors in locations that prevent surgical removal or whose tumor is progressive after surgery, prognosis is worse.

A majority of pediatric oncologists use cranial radiation to treat patients with unresectable or progressive brain tumors. Although radiation is often effective, the long-term effects such as mental impairment, hormonal deficiencies and increased rate of stroke late in life can be detrimental to young patients - causing some physicians and families to decide against treatment.

"This is the first large, multi-institutional study to investigate using chemotherapy as an alternative to cranial radiation," says Joann Ater, M.D., professor of pediatrics at the Children's Cancer Hospital at M. D. Anderson. "The results have confirmed the ability of chemotherapy to control the disease."

Ater is principal investigator for the Children's Oncology Group (COG) study and developed the Phase III trial, which compared two different chemotherapy regimens across three different patient groups. Smaller pilot studies have shown a carboplatin and vincristine (CV) regimen to be effective against low-grade glioma. However, the COG trial with 401 patients enrolled, showed that a thioguanine, procarbazine, lomustine and vincristine (TPCV) regimen was more effective than the CV regimen and resulted in a five-year event-free survival rate of nearly 50 percent.

Patients under 5 years old averaged 2.2 years before the disease progressed on the CV regimen, while patients between 5 to 10 years old, averaged 5.3 years before disease progression. Patients on the TPCV regimen fared better, with those 5 to 10 years old averaging more than eight years without disease progression. The trial also studied chemotherapy for neurofibromatosis patients who had low-grade gliomas. This patient population had the best response to chemotherapy among the three groups.

"If we can delay radiation, then we allow more time for our youngest patients to develop physically, which could decrease some of the long-term effects from treatment," Ater says. "This trial at least gives parents more information and alternative options when making decisions about their child's treatment."

Sara Farris | EurekAlert!
Further information:
http://www.mdanderson.org
http://www.mdanderson.org/children

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>