Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Parsley, Celery Carry Crucial Component for Fight Against Breast Cancer, MU Researcher Finds

10.05.2011
Parsley is usually used as a decorative accent to a scrumptious meal, but don’t set it aside just yet. In a new study, a University of Missouri researcher has found that a compound in parsley and other plant products, including fruits and nuts, can stop certain breast cancer tumor cells from multiplying and growing. The study was published recently in Cancer Prevention Research.

Salman Hyder, a University of Missouri researcher, has found that a compound in parsley can stop certain breast cancer tumor cells from multiplying and growing.

In his study, Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center, exposed rats with a certain type of breast cancer to apigenin, a common compound found in parsley and other plant products.

The rats that were exposed to the apigenin developed fewer tumors and experienced significant delays in tumor formation compared to those rats that were not exposed to apigenin. Hyder believes this finding could impact women who are taking certain hormone replacement therapies.

“Six to 10 million women in the United States receive hormone replacement therapy (HRT),” Hyder said. “We know that certain synthetic hormones used in HRT accelerate breast tumor development. In our study, we exposed the rats to one of the chemicals used in the most common HRTs received in the United States – a progestin called medroxyprogesterone acetate (MPA) – which also happens to be the same synthetic hormone that accelerates breast tumor development.”

When tumor cells develop in the breast in response to MPA, they encourage new blood vessels to form within tumors. The blood vessels then supply needed nutrients for the tumors to grow and multiply. Hyder found that apigenin blocked new blood vessel formation, thereby delaying, and sometimes stopping, the development of the tumors. Hyder also found that the compound reduced the overall number of tumors. However, while apigenin did delay tumor growth, it did not stop the initial formation of cancer cells within the breast.

Apigenin is most prevalent in parsley and celery, but can also be found in apples, oranges, nuts and other plant products. However, apigenin is not absorbed efficiently into the bloodstream, so scientists are unsure of how much can or should be ingested.

“We don’t have specific dosage for humans yet,” Hyder said. “However, it appears that keeping a minimal level of apigenin in the bloodstream is important to delay the onset of breast cancer that progresses in response to progestins such as MPA. It’s probably a good idea to eat a little parsley and some fruit every day to ensure the minimal amount. However, you can also find this compound in pill supplements in the health food section of many stores. Of course, you should always check with your doctor before making any major changes to your diet or lifestyle.”

The next phrase of studies should include human clinical trials to determine the appropriate dosage amount, Hyder said. He believes further study on humans is necessary to address any health and safety issues that might exist.

The research team included Benford Mafuvadze, doctoral student in biomedical sciences, Indira Benakanakere, research scientist Dalton Cardiovascular Research Center; Franklin Lopez, research fellow in the Department of Veterinary Pathobiology; Cynthia Besch-Williford, associate professor of veterinary pathobiology, and Mark Ellersieck, research professor of statistics in the College of Arts and Science.

Steven Adams | EurekAlert!
Further information:
http://www.missouri.edu

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>