“Currently, 1.6 billion adults are overweight or obese worldwide and over 50 percent of adults in the United States and Europe fit into this category,” said study author Weili Xu, MD, PhD, with the Karolinska Institutet in Stockholm, Sweden. “Our results contribute to the growing evidence that controlling body weight or losing weight in middle age could reduce your risk of dementia.”
Researchers studied information from the Swedish Twin Registry on 8,534 twins age 65 or older. Of those, 350 were diagnosed with dementia and 114 had possible dementia. Information on participant’s height and weight had been taken 30 years earlier.
Participants were grouped according to their body mass index (BMI), a measure of total body fat: underweight, normal weight, overweight and obese. Being overweight was defined as having a body mass index between 25 and 30 and obesity was defined as a body mass index of higher than 30. In the study, 2,541 twins, or nearly 30 percent, were either overweight or obese during middle age.
The study found that people who were overweight or obese at midlife had an 80 percent higher risk of developing dementia, Alzheimer’s disease or vascular dementia in late life compared to people with normal BMI. The results remained the same after considering other factors, such as education, diabetes and vascular disease. A total of 26 percent of those with no dementia had been overweight in midlife, compared to 36 percent of those with questionable dementia and 39 percent of those with diagnosed dementia. Three percent of those with no dementia had been obese in midlife, compared to five percent of those with questionable dementia and seven percent of those with diagnosed dementia.
The researchers also analyzed the data in twin pairs where one twin had dementia and one twin did not and found that there was no longer a significant relationship between overweight and obesity and dementia in midlife. “This suggests that early life environmental factors and genetic factors may contribute to the link between midlife overweight and dementia,” Xu said.
The study was supported by the National Institute on Aging, the Swedish Research Councils, the Swedish Brain Power, the Gamla Tjänarinnor Foundation, the Bertil Stohnes Foundation, the Swedish Dementia Fund, the Loo and Hans Ostermans Foundation, and the Foundation for Geriatric Diseases at Karolinska Institutet.
The American Academy of Neurology, an association of more than 24,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.
For more information about the American Academy of Neurology, visit http://www.aan.com.VIDEO: http://www.youtube.com/AANChannel
Angela M. Babb | American Academy of Neurology
Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT
Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
05.12.2016 | Power and Electrical Engineering
05.12.2016 | Materials Sciences
05.12.2016 | Power and Electrical Engineering