Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity linked to higher 5-year death rate after esophageal cancer surgery

21.12.2011
Obesity doubles the risk of cancer recurrence and cancer-related death in patients with esophageal cancer who have been treated with surgery, researchers at Mayo Clinic found.

Their 778-patient study, which appeared in the Dec. 1 issue of the Journal of Clinical Oncology (http://jco.ascopubs.org/), found that five-year survival in obese patients -- those with a body mass index of 30 or higher -- with esophageal cancer was 18 percent, compared to 36 percent in patients of normal weight.

VIDEO ALERT: Additional audio and video resources are available at the Mayo Clinic News Blog (http://newsblog.mayoclinic.org/2011/12/20/obesity-lowers-survival-chances-after-esophageal-cancer-surgery/).

The research is the first to find that obese patients with esophageal cancer have worse outcomes following surgery than patients with a normal weight, says lead investigator, Harry Yoon, M.D. (http://www.mayoclinic.org/bio/15120945.html), an oncologist at the Mayo Clinic Comprehensive Cancer Center (http://mayoresearch.mayo.edu/mayo/research/cancercenter/).

"Obesity is considered a risk factor in the development of this cancer, which is known to be both highly lethal and increasingly common," he says. "But prior to this study, we did not really understand the impact of obesity in this upper gastrointestinal cancer."

If validated in another study, the findings may change the way some physicians counsel obese patients with this disease Dr. Yoon says.

"As an oncologist, I did not typically speak to my patients about excess body weight as part of their care, because we are more often concerned about weight loss and maintaining proper nutrition, but that may change. It would be helpful to be able to offer patients some measures that they can take to possibly impact their prognosis," he says.

The study's findings applied to patients who had never smoked. Links between obesity and outcomes in smokers are more difficult to determine, because smoking is known to reduce weight and increase the likelihood of death. All the patients studied were treated at Mayo Clinic, and had undergone esophagectomy (removal of the esophagus), which is potentially curative.

Dr. Yoon says studies that have linked obesity with poor outcomes in other tumor types have proposed that excess weight produces a chronic inflammatory state, which can raise the risk of cancer development and worse outcomes.

The study was funded by the National Cancer Institute and the National Center for Research Resources.

About Mayo Clinic

Mayo Clinic is a nonprofit worldwide leader in medical care, research, and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about/ and http://www.mayoclinic.org/news

Joe Dangor | EurekAlert!
Further information:
http://www.mayo.edu

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>