In both groups 0.4 % of singletons were stillborn, with a definition of stillbirth as a dead child after 22 weeks of gestation. After having been matched with the control group regarding mother's parity and year of birth, the overall risk of stillbirth was found to be marginally higher (1.1 fold) in ART children after adjusting for factors such as maternal age and the child's sex.
"Although the difference in risk of stillbirth is significant between the two groups and the risk is marginally higher with an overrepresentation of 8 per 1,000 pregnancies for singleton ART pregnancies, the overall risk of stillbirth is still low," said Anna-Karina Aaris Henningsen, leading author of the study from Righospitalet University Hospital of Copenhagen. "This means that the individual woman need not be concerned about the risk of stillbirth during pregnancy."
When analysing the stillbirth risk before and after term, no difference was found after 40 weeks of gestation between ART children and their naturally conceived peers. This was also the case when comparing the two cohorts after 37 weeks of gestation. However, until gestational week 40, the group found a 1.2 fold higher risk of stillbirth for ART singletons.
"We believe the difference in risk of stillbirth between ART and NC children seems to occur before 37 weeks of gestation," said Dr. Aaris Henningsen. "It is likely, that some of the difference in risk of stillbirth is related to parental factors in the subfertile mother or father."
When the researchers assessed the risk of total perinatal death (risk of stillbirth and risk of perinatal death until one year of age), children born after ART showed a 1.4 fold increased risk compared to naturally conceived babies. This remained 1.2 fold higher after adjusting for confounding factors and can probably be partly explained by the higher risk of preterm birth among ART children.
"Very few European, non-Nordic, studies exist on stillbirth rates and are mostly based on small numbers," explained Dr. Aaris Henningsen. "Our results come from the largest database on ART children worldwide. The MART group is currently looking at multiple neonatal outcomes including the risk of perinatal death in both singletons and twins and is hoping to have additional data in the near future."
In 2006, the European IVF Monitoring Group (EIM), a working group of ESHRE decided to assess the possibility of using the Nordic ART registers to pool outcome data for infant and maternal health after ART. The Committee on Nordic ART and Safety (CoNARTaS) was established in order to provide a continuous and large scale Nordic monitoring system that reports on safety and quality aspects of ART. The Nordic ART database contains data on all ART pregnancies, deliveries and children born after IVF, Intracytoplasmic Sperm Injection (ICSI) and frozen embryo transfer (FET) in Denmark, Finland, Norway and Sweden.
Abstract no: O-300 Wednesday 6 July 2011, 14.30 hrs CEST (Room K1+K2)
Note: When obtaining outside comment, journalists are requested to ensure that their contacts are aware of the embargo on this release.
The figures in the release have been updated since the abstract was submitted to the conference.For further information on the details contained in this press release, contact:
Hanna Hanssen | EurekAlert!
Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)
The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
17.10.2017 | Life Sciences
17.10.2017 | Life Sciences
17.10.2017 | Earth Sciences