In both groups 0.4 % of singletons were stillborn, with a definition of stillbirth as a dead child after 22 weeks of gestation. After having been matched with the control group regarding mother's parity and year of birth, the overall risk of stillbirth was found to be marginally higher (1.1 fold) in ART children after adjusting for factors such as maternal age and the child's sex.
"Although the difference in risk of stillbirth is significant between the two groups and the risk is marginally higher with an overrepresentation of 8 per 1,000 pregnancies for singleton ART pregnancies, the overall risk of stillbirth is still low," said Anna-Karina Aaris Henningsen, leading author of the study from Righospitalet University Hospital of Copenhagen. "This means that the individual woman need not be concerned about the risk of stillbirth during pregnancy."
When analysing the stillbirth risk before and after term, no difference was found after 40 weeks of gestation between ART children and their naturally conceived peers. This was also the case when comparing the two cohorts after 37 weeks of gestation. However, until gestational week 40, the group found a 1.2 fold higher risk of stillbirth for ART singletons.
"We believe the difference in risk of stillbirth between ART and NC children seems to occur before 37 weeks of gestation," said Dr. Aaris Henningsen. "It is likely, that some of the difference in risk of stillbirth is related to parental factors in the subfertile mother or father."
When the researchers assessed the risk of total perinatal death (risk of stillbirth and risk of perinatal death until one year of age), children born after ART showed a 1.4 fold increased risk compared to naturally conceived babies. This remained 1.2 fold higher after adjusting for confounding factors and can probably be partly explained by the higher risk of preterm birth among ART children.
"Very few European, non-Nordic, studies exist on stillbirth rates and are mostly based on small numbers," explained Dr. Aaris Henningsen. "Our results come from the largest database on ART children worldwide. The MART group is currently looking at multiple neonatal outcomes including the risk of perinatal death in both singletons and twins and is hoping to have additional data in the near future."
In 2006, the European IVF Monitoring Group (EIM), a working group of ESHRE decided to assess the possibility of using the Nordic ART registers to pool outcome data for infant and maternal health after ART. The Committee on Nordic ART and Safety (CoNARTaS) was established in order to provide a continuous and large scale Nordic monitoring system that reports on safety and quality aspects of ART. The Nordic ART database contains data on all ART pregnancies, deliveries and children born after IVF, Intracytoplasmic Sperm Injection (ICSI) and frozen embryo transfer (FET) in Denmark, Finland, Norway and Sweden.
Abstract no: O-300 Wednesday 6 July 2011, 14.30 hrs CEST (Room K1+K2)
Note: When obtaining outside comment, journalists are requested to ensure that their contacts are aware of the embargo on this release.
The figures in the release have been updated since the abstract was submitted to the conference.For further information on the details contained in this press release, contact:
Hanna Hanssen | EurekAlert!
Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung
High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
26.10.2016 | Physics and Astronomy
26.10.2016 | Earth Sciences
25.10.2016 | Earth Sciences