Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NIH scientists identify mechanism responsible for spreading biofilm infections

07.12.2010
Finding could lead to treatment to prevent infection associated with catheters and medical implants

What: Scientists from the National Institutes of Health have discovered how catheter-related bacterial infection develops and disseminates to become a potentially life-threatening condition. The study, which included research on Staphylococcus epidermidis in mice implanted with catheters, could have important implications for understanding many types of bacterial biofilm infections, including those caused by methicillin-resistant S. aureus (MRSA).

Biofilms are clusters of microbes that almost always are found with healthcare-associated infections (HAIs) involving medical devices such as catheters, pacemakers and prosthetics. Most often biofilms that develop on such devices consist of Staph bacteria. Because biofilms inherently resist antibiotics and immune defenses, treating patients with biofilm-associated infections can be difficult and expensive. An estimated two million HAIs, most of which are associated with biofilms, occur in the United States annually, accounting for about 100,000 deaths.

Although biofilm-related infections result in significant numbers of deaths, scientists still have a limited understanding of how biofilms develop at a molecular level. But now scientists from NIH's National Institute of Allergy and Infectious Diseases (NIAID) have identified a specific S. epidermidis protein, called phenol-soluble modulin beta (PSM-beta), that biofilms use for multiple purposes: to grow, to detach from an implanted medical device, and to disseminate infection. Antibodies against PSM-beta slowed bacterial spread within the study mice, suggesting that interfering with biofilm development could provide a way to stop the spread of biofilm-associated infection.

Similar proteins also are found in S. aureus, and the research group now plans to study their role in biofilms of MRSA and other bacteria.

Article: R Wang et al. Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. The Journal of Clinical Investigation 121(1): DOI: 10.1172/JCI42520 (2011).

Who: Michael Otto, Ph.D., senior investigator, Laboratory of Human Bacterial Pathogenesis, NIAID. Dr. Otto is an expert in biofilms and Staphylococcus bacteria.

Contact: To schedule interviews, please contact Ken Pekoc, 301-402-1663, kpekoc@niaid.nih.gov.

NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

The National Institutes of Health (NIH)—The Nation's Medical Research Agency—includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

Ken Pekoc | EurekAlert!
Further information:
http://www.niaid.nih.gov

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>