The results were published online in Ophthalmology on Nov. 15, and presented on the same day in New Orleans at a joint meeting of the Eye Bank Association of America and the Cornea Society.
The Cornea Donor Study found that 10-year success rates remained steady at 75 percent for corneal transplants from donors 34 to 71 years old. It also found slightly higher success rates for donors under 34, and somewhat lower rates for donors over 71.
In the U.S., three-fourths of cornea donors are within the 34 to 71 age range, with one-third of donors at the upper end of the range, from 61 to 70 years old. When the study began in 2000, many surgeons would not accept corneas from donors over 65.
"The findings clearly demonstrate that most corneal transplants have remarkable longevity regardless of donor age," said Mark Mannis, chair of ophthalmology and vision sciences, director of UC Davis Health System's Eye Center and co-chair of the study. "The majority of patients continued to do well after 10 years, even those who received corneas from the oldest donors."
The Corneal Donor Study "supports continued expansion of the corneal donor pool beyond age 65," said study co-chair Edward J. Holland, professor of ophthalmology at the University of Cincinnati and director of the Cornea Service at the Cincinnati Eye Institute.Corneal disease and study design
The supply of corneas does not meet the demand internationally, and as the aging population grows at home and abroad, the need for corneal transplants is expected to grow, too. The Cornea Donor Study was designed to address whether making use of donor corneas across the full range of ages available might help solve this problem," said Maryann Redford, a clinical research program director at NEI.
The study (see NCT00006411 at http://clinicaltrials.gov) compared graft survival rates for corneas from two donor age groups, aged 12 to 65 and aged 66 to 75. Coordinated by the Jaeb Center for Health Research in Tampa, Fla., it involved 80 clinical sites across the U.S. and enrolled 1,090 people aged 40 to 80 who were eligible for transplants. Forty-three eye banks provided donor corneas, which met the quality standards of the Eye Bank Association of America. Patients received the corneas without respect to patient age using a transplant procedure called penetrating keratoplasty, in which the central part of the damaged cornea is removed, and a full-thickness donor cornea is sutured in its place.
About two thirds of patients had an inherited corneal disease called Fuchs' dystrophy, and one third had corneal swelling after cataract surgery. These conditions involve loss of cells in the innermost (endothelial) layer of the cornea and are leading reasons for corneal transplants reported to U.S. eye banks. Graft failure was defined as the need for a new transplant, or a cloudy cornea that caused blurred vision for at least three months.
The investigators originally planned to follow patients for five years post-transplant. In 2008, they reported that the five-year success rate was identical — 86 percent — for transplants from donors aged 12 to 65 and those aged 66 to 75. However, when the investigators examined endothelial cells in the transplanted corneas, they found that older corneas had a slightly higher rate of cell loss. Higher cell loss at six months also predicted a higher likelihood of graft failure at five years. That prompted an expansion of the study to determine if donor age would affect transplant viability 10 years after the procedure.Findings at 10-year mark
The investigators also re-evaluated the endothelial cells lining the inner cornea in a subgroup of 176 patients who had a successful transplant at 10 years and for whom high-quality images of the cells were available. The data confirmed the trend in cell loss seen at five years. At 10 years, corneas from donors over age 65 had a slightly higher rate of endothelial cell loss (79 percent) compared to those from donors age 65 and under (76 percent). The youngest corneas, from donors age 12 to 33, had the highest number of cells before surgery and the lowest rate of cell loss at 10 years (67 percent).
"The cell loss data parallels the graft survival data, but we don't yet know if a given number of cells at five years is predictive of graft failure at 10 years," said Jonathan Lass, professor of ophthalmology at Case Western Reserve University and University Hospitals Case Medical Center in Cleveland and medical director of the study's cornea image analysis reading center. That analysis is being done and will be released at a later date, he said.Penetrating vs. endothelial keratoplasty
Given the high success rate for transplants involving young donors (under age 34), the investigators wrote that their analysis "raises the question…of whether age-matching of donors and recipients is appropriate at the extremes of recipient age." Such age-matching is already a frequent practice for children and other young patients in need of corneal transplants, who routinely get corneas from young donors. But young donor corneas are relatively rare. In 2012, corneal donors under age 31 comprised less than 10 percent of the U.S. donor pool.
Surgeons often seek the youngest corneal tissue available regardless of patient age. Historically, some surgeons set extremely restrictive upper age limits, even refusing tissue from donors over age 50, Mannis said.
"The study demonstrates the viability of older donor tissue in the majority of cases with endothelial disease," he said. "In time, we hope the study will have a lasting impact on the practice of corneal transplant surgery. Although the results suggest that age-matching may be appropriate for the very youngest donors and patients, we do not think it is necessary in the vast majority of cases."
The Cornea Donor Study was funded through cooperative agreements EY012728 and EY012358 from NEI. Additional support was provided by the Eye Bank Association of America, Bausch & Lomb, Tissue Banks International, Vision Share, San Diego Eye Bank, The Cornea Society, Katena Products, ViroMed Laboratories, Midwest Eye-Banks (Michigan Eye-Bank, Illinois Eye-Bank, Cleveland Eye Bank, and Lions Eye Bank of New Jersey), Konan Medical Corp., Eye Bank for Sight Restoration, SightLife, Sight Society of Northeastern New York (Lions Eye Bank of Albany), and Lions Eye Bank of Oregon.
NEI leads the federal government's research on the visual system and eye diseases. NEI supports basic and clinical science programs that result in the development of sight-saving treatments. For more information, visit http://www.nei.nih.gov.
UC Davis Health System improves health and health care, around the corner and across the globe. Diverse in expertise but united in purpose, UC Davis faculty, staff and students collaborate daily to solve urgent real-world problems, translate research into new cures and eliminate health disparities. Whether treating complex injuries, improving cancer care or explaining autism, UC Davis Health System's unique combination of academic excellence and social responsibility advances health for all. For more information, visit http://healthsystem.ucdavis.edu.
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy