79 million American adults have prediabetes and will likely develop diabetes later in life, according to the Centers for Disease Control and Prevention. As the number of people diagnosed with diabetes continues to grow, researchers are focusing on discovering why the prevalence of the disease is increasing.
John Thyfault, an assistant professor in MU’s departments of Nutrition and Exercise Physiology and Internal Medicine, has found that ceasing regular physical activity impairs glycemic control (control of blood sugar levels), suggesting that inactivity may play a key role in the development of type 2 diabetes.John Thyfault found that physical inactivity disrupts control of blood sugar levels and plays a key role in the development of type 2 diabetes.
“We now have evidence that physical activity is an important part of the daily maintenance of glucose levels,” Thyfault said. “Even in the short term, reducing daily activity and ceasing regular exercise causes acute changes in the body associated with diabetes that can occur before weight gain and the development of obesity.”
Thyfault studied the relationship between low levels of physical activity and elevated levels of postprandial glucose (PPG), or the spikes in blood sugar that occur after a meal. PPG is a risk factor for the development of type 2 diabetes and has been associated with increased incidences of cardiovascular disease and death. Thyfault found that when healthy individuals reduced their physical activity by about half for three days, their PPG responses to meals doubled.
“A single bout of moderate exercise can improve the way the body maintains glucose homeostasis (blood glucose regulation) and reduce PPG, but becoming inactive for a short period of time quickly disrupts glucose homeostasis,” Thyfault said. “This study shows that physical activity directly impacts health issues that are preventable.”
In the study, Thyfault monitored the activity levels and diets of healthy and moderately active young adults. Participants then reduced their physical activity by 50 percent for three days while replicating the diet they consumed when they were active. Continuous glucose monitors worn by the subjects during the period of inactivity revealed significantly increased levels of PPG. Spikes in blood glucose after meals can indicate increased risks for type 2 diabetes and cardiovascular disease.
“It is recommended that people take about 10,000 steps each day,” Thyfault said. “Recent evidence shows that most Americans are only taking about half of that, or 5,000 steps a day. This chronic inactivity leads to impaired glucose control and increases the risk of developing diabetes.”
The study, “Lowering Physical Activity Impairs Glycemic Control in Healthy Volunteers,” will be published in Medicine & Science in Sports & Exercise. It was funded by the University of Missouri Institute for Clinical and Translational Sciences, the MU Research Council and the National Institutes of Health (NIH). The Department of Nutrition and Exercise Physiology is jointly administered by MU’s College of Agriculture, Food and Natural Resources, College of Human Environmental Sciences and School of Medicine. Thyfault has a joint appointment in the Department of Internal Medicine in the School of Medicine.
Samantha Craven | EurekAlert!
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
16.03.2018 | Earth Sciences
16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences