Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MRI scans show structural brain changes in people at risk for Alzheimer's disease

17.11.2010
Study suggests an early marker for dementia may help identify candidates for possible early treatment

New results from a study by neuroscientists at Rush University Medical Center suggest that people at risk of developing Alzheimer's disease exhibit a specific structural change in the brain that can be visualized by brain imaging. The findings may help identify those who would most benefit from early intervention.

The study will be presented at Neuroscience 2010, the annual meeting for the Society of Neuroscience in San Diego, Calif., on Wednesday, November 17.

"One of the main challenges in the field of Alzheimer's disease is identifying individuals at risk of developing Alzheimer's disease so that therapeutic interventions developed in the future can be given at the earliest stage before symptoms begin to appear," said Sarah George, a graduate student who co-authored the study with Leyla deToledo-Morrell, PhD, director of the graduate program in neuroscience at Rush University Medical Center and professor of neurological sciences at the Graduate College of Rush University.

"Our study has found that structural imaging techniques can be used to identify those at risk for developing Alzheimer's disease," said deToledo-Morrell.

For the study, experts from Rush followed individuals with mild cognitive impairment, which is thought to be a precursor of Alzheimer's disease and other forms of dementia. Those with mild cognitive impairment can exhibit memory decline known as amnestic mild cognitive impairment.

Researchers followed 52 individuals with amnestic mild cognitive impairment over a period of six years. Twenty-three participants progressed to Alzheimer's disease.

Study participants underwent magnetic resonance imaging (MRI) screenings. The researchers used MRI to look for structural changes in the substantia innominata (SI), a region deep within the brain that sends chemical signals to the cerebral cortex, the brain's outer layer that is largely responsible for reasoning, memory and other higher functions. Although no structural changes were found in the SI between the two groups, the MRI showed a thinning of the cortical areas that receive strong input from the SI in those who went on to develop Alzheimer's disease.

"Since we were able to distinguish those who progressed to Alzheimer's disease compared to those who remained stable, we believe that MRI techniques that examine patterns of structural alterations provide a sensitive biomarker for detecting risk of Alzheimer's disease," said George.

Additional co-authors on the study include Elliott J. Mufson, PhD., professor of neurological sciences at Rush University Medical Center, and Dr. Raj C. Shah, director of the memory clinic at the Rush Alzheimer's Disease Center at Rush University Medical Center.

Rush University Medical Center is a 676-bed academic medical center that includes Rush Children's Hospital, the Johnston R. Bowman Health Center (a 61-bed rehabilitation facility), and Rush University. Rush is a not-for-profit health care, education and research enterprise. Rush University is home to one of the first medical colleges in the Midwest and includes one of the nation's top-ranked nursing colleges, as well as graduate programs in allied health, health systems management and biomedical research.

Deb Song | EurekAlert!
Further information:
http://www.rush.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>