Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Moderate Drinking is Healthy Only for Some People

10.11.2014

A new study at Sahlgrenska Academy, University of Gothenburg, confirms that moderate alcohol consumption can protect against coronary heart disease. But only for the 15% of the population that have a particular genotype.

The study included 618 Swedes with coronary heart disease and a control group of 3,000 healthy subjects. The subjects were assigned to various categories based on the amount of alcohol they consumed (ethanol intake). Meanwhile, they were tested in order to identify a particular genotype (CETP TaqIB) that previous studies had found to play a role in the health benefits of alcohol consumption.


Professor Dag Thelle, Sahlgrenska Academy, University of Gothenburg

University of Gothenburg

Protective effect
The results, which have been published in Alcohol, confirm the findings of the earlier studies. Moderate consumption of alcohol helps protect people with the genotype against coronary heart disease.

"In other words, moderate drinking has a protective effect among only 15% of the general population," says Professor Dag Thelle, Professor Emeritus at Sahlgrenska Academy, University of Gothenburg.

Sweeping advice
Thus, the researchers believe that the advice frequently given about the health benefits of moderate alcohol consumption is far too sweeping.

"Moderate drinking alone does not have a strong protective effect," says Professor Lauren Lissner, who also participated in the study. "Nor does this particular genotype. But the combination of the two appears to significantly reduce the risk of coronary heart disease."

Unknown mechanisms
The genotype codes for the Cholesterylester transfer protein (CETP), which affects the 'good,' cardio-protective HDL cholesterol that helps remove excess lipids from the blood vessels. One hypothesis is that alcohol somehow affects the CETP in a way that benefits HDL cholesterol.

A second hypothesis is that alcohol contains healthy, protective antioxidants.

The researchers believe that one or both of the hypotheses may prove correct, but the mechanisms by which HDL cholesterol or antioxidants might act remain unknown.

"Our study represents a step in the right direction," Professor Thelle says, "but a lot more research is needed. Assuming that we are able to describe these mechanisms, it may be a simple matter one day to perform genetic testing and determine whether someone belongs to the lucky 15%. That would be useful to know when offering advice on healthy alcohol consumption. But the most important thing is to identify new means of using the body's resources to prevent coronary heart disease."

The article CETP TaqIB genotype modifies the association between alcohol and coronary heart disease: The INTERGENE case-control study was published online in Alcohol on September 17, by lead author Kirsten Mehlig and colleagues.

Link to article: http://www.sciencedirect.com/science/article/pii/S0741832914200565

Contact:
Professor Dag Thelle, Sahlgrenska Academy, University of Gothenburg
phone +46 709-458024
epidag@gmail.com

Professor Lauren Lissner, Sahlgrenska Academy, University of Gothenburg
phone +46 31-7866847, +46 708-207343
lauren.lissner@gu.se


Weitere Informationen:

http://www.sahlgrenska.gu.se/english/news_and_events/news/News_Detail//moderate-drinking-is-healthy-only-for-some-people.cid1242619

Henrik Axlid | idw - Informationsdienst Wissenschaft

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Positrons as a new tool for lithium ion battery research: Holes in the electrode

22.02.2017 | Power and Electrical Engineering

New insights into the information processing of motor neurons

22.02.2017 | Life Sciences

Healthy Hiking in Smart Socks

22.02.2017 | Innovative Products

VideoLinks
B2B-VideoLinks
More VideoLinks >>>