Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mild Memory Loss Is Not a Part of Normal Aging

16.09.2010
Study at Rush University Medical Center links earliest stages of cognitive decline to lesions in the brain

Simply getting older is not the cause of mild memory lapses often called senior moments, according to a new study by researchers at the Rush Alzheimer’s Disease Center.

The study, published in the September 15, 2010, online issue of Neurology, the medical journal of the American Academy of Neurology, found that even the very early mild changes in memory that are much more common in old age than dementia are caused by the same brain lesions associated with Alzheimer’s disease and other dementias.

“The very early mild cognitive changes once thought to be normal aging are really the first signs of progressive dementia, in particular Alzheimer’s disease.” said Robert S.Wilson, PhD, neuropsychologist at Rush University Medical Center. “The pathology in the brain related to Alzheimer’s and other dementias has a much greater impact on memory function in old age than we previously recognized.”

The study involved over 350 nuns, priests and brothers who participated in Rush’s Religious Orders Study and completed up to 13 years of annual cognitive testing. After death, the brains were examined for the lesions associated with dementia: neurofibrillary tangles, cerebral infarction (stroke), and Lewy bodies.

Researchers looked at the rate of change in cognitive function over time. The last four to five years of life showed a very rapid decline. The preceding years showed a much more gradual decline that would be described as normal aging.

As expected, pathologic lesions were related to the rapid decline, but researchers were somewhat surprised to find the pathology was very strongly predictive of the mild changes in cognitive function.

Higher tangle density adversely affected all forms of cognition at all trajectory points. Both Lewy bodies and stroke approximately doubled the rate of gradual memory decline, and almost no gradual decline was seen in the absence of lesions.

“Our study finds that Alzheimer’s disease and related dementias are the root cause of virtually all loss of cognition and memory in old age. They aren’t the only contributing factors; other factors affect how vulnerable we are to the pathology and to its effects. But the pathology does appear to be the main force that is driving cognitive decline in old age,” said Wilson.

According to Wilson, recognizing that the earliest changes in memory are related to Alzheimer’s pathology can lead to early diagnosis and will be critical information if a treatment is developed that can alter the pathologic course of the disease.

The study was supported by the National Institute on Aging. Co-authors include Sue Leurgans, PhD; Patricia Boyle, PhD; Dr. Julie Schneider and Dr. David Bennett.

The Rush Alzheimer's Disease Center (RADC) is one of 29 Alzheimer's disease research centers across the country designated and funded by the National Institute on Aging. The center is dedicated to reducing disability due to Alzheimer's disease and other age-related conditions through research on the treatment and prevention of disease for this and future generations. Since 1985, the RADC has provided services to more than 5,000 Alzheimer's patients and their families through its outpatient clinic.

Kim Waterman | EurekAlert!
Further information:
http://www.rush.edu

Further reports about: Alzheimer Disease Lewy Medical Wellness Neurology RADC Rush brain aging cognitive function

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>