Each year more than 6,000 adults in the United States are living kidney donors. Over time, these donors typically have some decline in function of their remaining kidney, depending on their age and other factors. However, the new study found that kidney function decreases more than twice as fast in donors who have a cluster of cardiovascular risk factors known as the metabolic syndrome.
"The metabolic syndrome before kidney donation can negatively affect a donor's kidney function outcome," said the study's lead author, Daniel Cuevas-Ramos, MD, a clinical researcher at Mexico's Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. "We recommend that living kidney donors correct any metabolic abnormalities before donation."
Diagnosis of the metabolic syndrome depends on the presence of at least three of the following: a large waistline, low HDL ("good") cholesterol, high triglycerides (levels of fat in the blood), high blood pressure and high blood glucose (blood sugar) at a level considered prediabetes or above. The metabolic syndrome, which affects one in five people in the United States, increases the chance of developing Type 2 diabetes, heart disease and stroke.
Cuevas-Ramos and his colleagues studied 140 adults who donated a kidney. Of those, 28 donors had the metabolic syndrome before donation and 112 did not. Using long-term follow-up data, the investigators determined each donor's kidney function after donation, measured by the glomerular filtration rate, or GFR, on a blood test. In general, a GFR below 70 milliliters per minute indicates below-normal kidney function.
The average time it took for donors' GFR to drop below 70 was less than six years in those who had the metabolic syndrome before donation versus approximately 13 years in donors without the syndrome.
"This study does not suggest that the metabolic syndrome is a contraindication for kidney donation but rather another potential risk factor for decline in renal function," Cuevas-Ramos said.
Medical reasons for rejecting a kidney donor, called contraindications, vary among U.S. transplant centers. However, diabetes, obesity, and high blood pressure are usually contraindications to donating a kidney.
Aaron Lohr | EurekAlert!
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences