Each year more than 6,000 adults in the United States are living kidney donors. Over time, these donors typically have some decline in function of their remaining kidney, depending on their age and other factors. However, the new study found that kidney function decreases more than twice as fast in donors who have a cluster of cardiovascular risk factors known as the metabolic syndrome.
"The metabolic syndrome before kidney donation can negatively affect a donor's kidney function outcome," said the study's lead author, Daniel Cuevas-Ramos, MD, a clinical researcher at Mexico's Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. "We recommend that living kidney donors correct any metabolic abnormalities before donation."
Diagnosis of the metabolic syndrome depends on the presence of at least three of the following: a large waistline, low HDL ("good") cholesterol, high triglycerides (levels of fat in the blood), high blood pressure and high blood glucose (blood sugar) at a level considered prediabetes or above. The metabolic syndrome, which affects one in five people in the United States, increases the chance of developing Type 2 diabetes, heart disease and stroke.
Cuevas-Ramos and his colleagues studied 140 adults who donated a kidney. Of those, 28 donors had the metabolic syndrome before donation and 112 did not. Using long-term follow-up data, the investigators determined each donor's kidney function after donation, measured by the glomerular filtration rate, or GFR, on a blood test. In general, a GFR below 70 milliliters per minute indicates below-normal kidney function.
The average time it took for donors' GFR to drop below 70 was less than six years in those who had the metabolic syndrome before donation versus approximately 13 years in donors without the syndrome.
"This study does not suggest that the metabolic syndrome is a contraindication for kidney donation but rather another potential risk factor for decline in renal function," Cuevas-Ramos said.
Medical reasons for rejecting a kidney donor, called contraindications, vary among U.S. transplant centers. However, diabetes, obesity, and high blood pressure are usually contraindications to donating a kidney.
Aaron Lohr | EurekAlert!
Physics of bubbles could explain language patterns
25.07.2017 | University of Portsmouth
Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.
At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
25.07.2017 | Physics and Astronomy
25.07.2017 | Earth Sciences
25.07.2017 | Life Sciences