Published in the journal Cell, the results highlight the role of the transcription factor dATF-2 in chromatin assembly, marking a major advance in our understanding of non-Mendelian inheritance.
Recent years have seen growing interest in the phenomenon of epigenetic inheritance: the idea that our genome, through epigenetic tags and other structural modifications, transmits more information than the sequence of letters encoded in its DNA base pairs alone. Stresses of various kinds have been shown to induce such epigenetic change, yet the underlying mechanisms involved remain unknown.
To clarify these mechanisms, the researchers investigated the activity of activation transcription factor-2 (ATF-2), a member of a family of transcription factors which regulate gene expression in response to changes in the cellular environment. Earlier research had suggested that in the absence of stress, ATF-2 plays a role in silencing certain genes through the formation of heterochromatin, a tightly-packed variety of chromatin whose state is epigenetically heritable. When the stress is turned on, ATF-2 changes its function and induces gene expression.
Most interestingly, the researchers discovered that the disruption to heterochromatin caused by the release of dATF-2 was transmitted to the next generation of cells, without any change to their DNA sequences.In the case of heat shock, sustained stress over multiple generations resulted in the altered chromatin state being inherited by subsequent generations as well. The findings thus provide the first example of multigenerational transmission of stress-induced epigenetic change, highlighting the role played by ATF-2 and opening promising new avenues for further study.
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland
Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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24.03.2017 | Physics and Astronomy