Cornelia Ulrich, Ph.D., and colleagues measured the levels of C-reactive protein (CRP) and serum amyloid A (SAA) in 734 breast cancer patients at 31 months after diagnosis. They found that elevated levels of CRP and SAA are associated with reduced overall survival, regardless of patient age, tumor stage, race and body mass index.
For example, women with breast cancer who had SAA levels that were in the highest third in amount measured in their blood were three times more likely to die from their disease within the following seven years compared to patients with the lowest-third amount. Similarly, women in the highest third of CRP levels had a two-fold increased risk of death.
"These associations are strong and they suggest that, in the long-term, elevated levels of inflammatory markers predict a woman's chances of surviving after breast cancer," said Ulrich, a member in the Hutchinson Center's Cancer Prevention Program. "It also appears that there may be a threshold effect in that only women in the highest third of inflammation markers had increased mortality."
The study appears in the May 18 edition of the Journal of Clinical Oncology.
"To our knowledge, this is the largest population-based cohort study to date that examined the relationship between systemic inflammation and breast cancer survival, and the first to evaluate SAA as a prognostic marker for breast cancer," said Ulrich.
CRP and SAA are nonspecific, acute-phase hepatic proteins that are secreted into the circulating blood stream in response to cytokines including interleukin-1, interleukin-6 and tumor necrosis factor.
Patient data was drawn from the Health, Eating, Activity and Lifestyle (HEAL) study, a multi-ethnic NIH-funded prospective group of women diagnosed with stage 0 through Stage IIIa breast cancer.
In previous studies, elevated CRP was associated with poor survival in patients with metastatic prostate cancer as well as those with gastroesophogeal, colorectal, inoperable small-cell lung and pancreatic cancers. Preoperative levels of SAA have been associated with survival of patients with gastric cancer and those with renal cell carcinoma.
Likewise, clinical and experimental data suggest that chronic inflammation promotes mammary tumor development. Breast cancer patients have elevated concentrations of CRP before surgery, more so in women with advanced disease, which suggests that CRP may be related to tumor burden or progression.
Cancer survivors with chronic inflammation may have an elevated risk of recurrence as a result of the effects of inflammatory processes on cell growth or the presence of cancer cells that induce inflammation, according to the study.
"It is interesting that markers measured in the blood nearly three years after diagnosis predicted prognosis," Ulrich said. "We also found these associations to hold up after adjusting for a number of factors that associate with systemic inflammation, such as obesity. However, more research is needed to confirm these findings and to get more precise estimates of risk. We also need to learn more about the biologic mechanisms."
Ulrich was joined in this study by researchers from the University of Washington, the National Cancer Institute, City of Hope National Medical Center, University of Southern California and the University of Louisville.
Funding for the study was provided by the National Cancer Institute, National Institutes of Health, National Institute of Child Health and Human Development, University of New Mexico, University of Chicago and the California Department of Health.
(Note to editors/reporters: For a copy of the paper "Elevated Biomarkers of Inflammation are Associated with Reduced Survival Among Breast Cancer Patients," please contact Kelly Powell, American Society of Clinical Oncology, at 571-483-1365 or Kelly.email@example.com)
At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit fhcrc.org.
Dean Forbes | EurekAlert!
Further reports about: > Body Mass Index > C-reactive protein > CRP > Cancer > Health > Interleukin-6 > Oncology > acute-phase hepatic proteins > breast cancer > cancer patients > chronic inflammation > cytokines > inflammation markers > inflammatory process > inoperable small-cell lung > metastatic prostate cancer > pancreatic cancer > pancreatic cancers > renal cell carcinoma > serum amyloid A > tumor necrosis factor
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy