The goal is to understand which tumors will be difficult to treat and to find out why certain cancer drugs lose their effect after a period of use. The study is to be directed by Tobias Sjöblom, associate professor of tumor biology at Uppsala University, Sweden.
The study involves a hundred cancer patients, suffering from either cancer of the large intestine or chronic lymphatic leukemia. Samples will be taken from patients both before and after drug treatment. The aim is to find out what makes so many tumors resistant to treatment – a major problem in cancer care today.
“With this initiative we will have a unique opportunity to study the development of tumors up close. Several research teams will examine the samples using different analytical methods in order to get an overall picture,” says Tobias Sjöblom, associate professor of tumor biology at Uppsala University and director of the study.
What lies behind this resistance is not known today, but it is assumed to emerge when the tumor changes over time, mutates. This also alters the original approach to treatment. In the study scientists will be looking for mutations in all the genes in the tumors.
The study is to be performed by Uppsala scientists together with colleagues from the Royal Institute of Technology, the Swedish University of Agricultural Sciences, and Umeå University. It is made possible by funding from SciLifeLab, a total of SEK 4.5 million over two years. All analyses will be done at SciLifeLab, which is a national resource center for medical and bioscience research.
“This is a model for how we want to work with large projects within SciLifeLab. Researchers receiving funding from us have access to our resources in the form of technologically advanced equipment and competence, while their own expertise in the specific research field ensures that the right questions are being asked. This enables us to generate new knowledge about diseases more quickly,” says Kerstin Lindblad-Toh, director of SciLifeLab Uppsala.
This type of research is also of interest to the pharmaceuticals industry.
“The industry will have an opportunity to assess the effect of their drugs, and we hope this will provide greater insights into how we can predict how different patients will react to a certain medicine in the future,” says Tobias Sjöblom.
SciLifeLab is funding a number of major and minor projects in 2011.
For more information about the study, please contact:
Tobias Sjöblom, Department of Immunology, Genetics, and Pathology, Uppsala University, tel: +46 (0)18-4715036, or mobile: +46 (0)701-67 90 39, e-mail: firstname.lastname@example.org
Professor Kerstin Lindblad-Toh, director of SciLifeLab, tel: +46 (0)18- 4714386, e-mail: email@example.com
Uppsala universitet - kvalitet, kunskap och kreativitet sedan 1477.. Forskning i världsklass och högklassig utbildning till global nytta för samhälle, näringsliv och kultur. Uppsala universitet är ett av norra Europas högst rankade lärosäten.
Linda Koffmar | Uppsala universitet
Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung
Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
17.08.2017 | Physics and Astronomy
17.08.2017 | Earth Sciences
17.08.2017 | Physics and Astronomy