Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lumbar disc degeneration more likely in overweight and obese adults

30.01.2012
Elevated BMI linked to greater extent and severity of degenerative disc disease

One of the largest studies to investigate lumbar spine disc degeneration found that adults who are overweight or obese were significantly more likely to have disc degeneration than those with a normal body mass index (BMI).

Assessments using magnetic resonance imaging (MRI) show elevated BMI is associated with an increased number of levels of degenerated disks and greater severity of disc degeneration, including narrowing of the disc space. Details of this study now appear in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR).

The World Health Organization (WHO) reports that obesity—one of the most preventable risk factors for a number of diseases—has more than doubled since 1980. According to WHO, in 2008 roughly 1.5 billion people aged 20 and older were overweight, with more than 200 million men and close to 300 million women considered obese. In the U.S., studies estimate one in three children is overweight or obese and excess weight could lead to more severe obesity in adulthood.

Moreover, previous research has linked higher BMI to low back pain, which is often debilitating and can limit function, impact psychological well being, diminish overall quality of life, and is associated with substantial socioeconomic and health-care costs. Experts suggest that disc degeneration is one cause of low back pain, and therefore, BMI could be involved in the development of degenerative disc disease. To expand the knowledge of this important health concern, a team of researchers led by Drs. Dino Samartzis and Kenneth M.C. Cheung at the University of Hong Kong in Hong Kong investigated the association between elevated BMI and presence, extent, and severity of lumbar spine disc degeneration on MRI in adults.

The team recruited 2,599 participants aged 21 and older from Southern China between 2001 and 2009. Participants were from diverse social and economic backgrounds and were recruited regardless of whether they had lower back pain or not. The study group included 1,040 men and 1,559 women who had a mean age of 42 years. Researchers conducted radiographic and clinical assessments, and MRIs of the lumbar spine were obtained for all subjects.

Study findings reveal that 73% of participants displayed disc degeneration, with men (76%) having a significantly higher prevalence of degeneration than women (71%). Not surprisingly, increasing age was found to increase the prevalence of disc degeneration. BMI assessments of the study group show that 7% of subjects were underweight, 48% were in the normal weight range, 36% were overweight, and 9% were obese.

"Our research confirms that with elevated BMI there is a significant increase in the extent and global severity of disc degeneration. In fact, end-stage disc degeneration with narrowing of the disc space was more pronounced in obese individuals," said Dr. Samartzis. The authors suggest that with weight gain, physical loading on the disc and/or a chronic low-grade inflammation from the fat cells may play a role in disc degeneration. Dr. Samartzis further added that "Since overweight and obesity are worldwide concerns whose prevalence continues to rise, our study's findings have considerable public health implications. If these issues continue to plague society, they can further affect spine health leading to low back pain and its consequences."

The authors note that disc degeneration is a complex process involving structural and chemical changes of the disc. They recommend that future studies that investigate risk factors for disc degeneration should take into account the impact of overweight and obesity on the disease. Dr. Cheung concludes, "Deeper understanding of how elevated BMI contributes to disc degeneration and low back pain could aid in the development of novel interventions that can improve quality of life for those with these disabling conditions."

This study is published in Arthritis & Rheumatism. Media wishing to receive a PDF of this article may contact healthnews@wiley.com

Full citation: "The Association of Lumbar Intervertebral Disc Degeneration on MRI in Overweight and Obese Adults: A Population-Based Study." Dino Samartzis, Jaro Karppinen, Danny Chan, Keith D.K. Luk and Kenneth M.C. Cheung. Arthritis & Rheumatism; Published Online: January 30, 2012 (DOI: 10.1002/art.33462).

URL Upon publication: http://doi.wiley.com/10.1002/art.33462.

Author Contact: Dr. Samartzis can be reached at dsamartzis@msn.com or +852 9584-2395.

About the Journal:

Arthritis & Rheumatism is an official journal of the American College of Rheumatology (ACR) and the Association of Rheumatology Health Professionals (ARHP), a division of the College, and covers all aspects of inflammatory disease. The American College of Rheumatology (www.rheumatology.org) is the professional organization who share a dedication to healing, preventing disability, and curing the more than 100 types of arthritis and related disabling and sometimes fatal disorders of the joints, muscles, and bones. Members include practicing physicians, research scientists, nurses, physical and occupational therapists, psychologists, and social workers. The journal is published by Wiley-Blackwell on behalf of the ACR. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1529-0131.
About Wiley-Blackwell:

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

Dawn Peters | EurekAlert!
Further information:
http://www.wiley.com

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>