Atopic dermatitis (also known as atopic eczema) is a chronic and extremely painful inflammation of the skin that frequently occurs in early childhood, generally already in infancy. Up to 20 percent of all children in industrialized countries are affected, making it one of the most common childhood skin diseases.
The need to better understand this disease is all the greater considering the intense suffering it causes in small children. Atopic dermatitis is, however, an allergic condition and all allergic reactions result from complex interactions of genetic and environmental factors on the immune system. Earlier research has already indicated that allergies are less common in children who grow up on farms and whose mothers live on farms during their pregnancy. Exposure to farm animals and bacteria frequently found in farms as well as drinking milk from the dairy offer the immune system protection. However, proof of this protective effect in connection with atopic dermatitis has remained elusive.
Now, the «Journal of Allergy & Clinical Immunology» (JACI) has published a study by Caroline Roduit from the research team of Roger Lauener, University of Zurich. The study analyzes how prenatal environmental factors and genetic mechanisms influence the development of atopic dermatitis during the first two years of life. The authors of the study examined children in rural areas of five European countries: Austria, Finland, France, Germany and Switzerland. Of the 1,063 children taking part in the study, 508 were from families that lived on farms, 555 were not farm children.
The researchers were able to demonstrate that women who spend their pregnancy in the proximity of farm animals and cats have children with a reduced risk of developing atopic dermatitis in their first two years of life. The research team also identified two genes in these children that are of vital importance for innate immunity and was able to link the expression of these genes to a lower likelihood of a doctor diagnosis of an allergic condition. The findings of the study are not only significant in the face of the frequency of the disease and the suffering it causes: They also support the theory that gene-environment interaction with the developing immune system influences the development of atopic dermatitis in young children.
Beat Müller | idw
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
24.04.2017 | Life Sciences
24.04.2017 | Earth Sciences
24.04.2017 | Machine Engineering