The study, involving 797 patients transplanted between 1998 and 2004 and followed for at least five years, shows that 87 percent of patients have mild or no signs of progressive scar damage to the transplanted organ when biopsied at one year after transplant.
This number decreases only slightly at the five-year mark (83 percent). In contrast, studies of patients transplanted in the early 1990s suggested that a majority of transplanted kidneys were affected by progressive scarring that ultimately led to failure of the transplant.
"These results are significant and encouraging for everyone who is concerned about long-term survival for kidney transplant patients," says Mark Stegall, M.D., (http://www.mayoclinic.org/bio/12971332.html) transplant surgeon at Mayo Clinic. "Our results suggest that transplanted kidneys may be doing better than reports from prior eras have indicated."
The Mayo Clinic study is published in the April 2011 issue of the American Journal of Transplantation (http://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2010.03312.x/abstract).
Patients in the study received a kidney transplant at Mayo Clinic in Rochester, Minn. As part of normal follow-up care, the patients were encouraged to return for checkups at four months, one year, two years and five years post-transplant. Kidney biopsies, as well as renal function measures and other tests, were routinely taken at these milestones. While fewer patients returned for checkups over time, a subgroup of 296 patients underwent biopsies at the one-year and five-year mark, allowing the researchers the opportunity to directly monitor changes in the kidney over time.
Using this information, researchers found that 47 percent of patients had minimal fibrosis (scarring) and 40 percent had mild fibrosis (87 percent total) one year after transplant. At five years after transplant, the numbers changed slightly, with 38 percent showing minimal fibrosis and 45 percent showing mild fibrosis (83 percent total). Results were similar for kidneys transplanted from living and deceased donors.
Dr. Stegall explains that minimal or mild fibrosis does not interfere significantly with kidney function. However, the development of severe scarring interferes with the kidney's ability to function and may result in the patient needing to start dialysis or undergo a second transplant.
Key to the study was that biopsies were routinely taken at post-transplant checkups. "That information allowed us to better understand what happens over those five years," says Walter Park, Mayo Clinic associate in the Department of Surgery (http://www.mayoclinic.org/surgery/) who analyzed the study data. "We now know that when patients have mild fibrosis at one year, it doesn't mean that it will progress to severe fibrosis at five years."
The research team will continue its work to learn more about why some kidneys still develop problems and how to avoid them. They also are interested in determining if kidneys that are doing well at five years are still prone to injury later.
VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. Mark Stegall, are available on the Mayo Clinic News Blog (http://dev.newsblog.mayoclinic.org/2011/04/07/kidney-transplant-study/).
Mayo Clinic in Rochester is one of the largest kidney transplant centers in the United States. In 2010, Mayo Clinic surgeons provided 198 patients with transplanted kidneys; 144 of those were from living donors.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit www.mayoclinic.org/about/ and www.mayoclinic.org/news.
Ginger Plumbo | EurekAlert!
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy