The study, involving 797 patients transplanted between 1998 and 2004 and followed for at least five years, shows that 87 percent of patients have mild or no signs of progressive scar damage to the transplanted organ when biopsied at one year after transplant.
This number decreases only slightly at the five-year mark (83 percent). In contrast, studies of patients transplanted in the early 1990s suggested that a majority of transplanted kidneys were affected by progressive scarring that ultimately led to failure of the transplant.
"These results are significant and encouraging for everyone who is concerned about long-term survival for kidney transplant patients," says Mark Stegall, M.D., (http://www.mayoclinic.org/bio/12971332.html) transplant surgeon at Mayo Clinic. "Our results suggest that transplanted kidneys may be doing better than reports from prior eras have indicated."
The Mayo Clinic study is published in the April 2011 issue of the American Journal of Transplantation (http://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2010.03312.x/abstract).
Patients in the study received a kidney transplant at Mayo Clinic in Rochester, Minn. As part of normal follow-up care, the patients were encouraged to return for checkups at four months, one year, two years and five years post-transplant. Kidney biopsies, as well as renal function measures and other tests, were routinely taken at these milestones. While fewer patients returned for checkups over time, a subgroup of 296 patients underwent biopsies at the one-year and five-year mark, allowing the researchers the opportunity to directly monitor changes in the kidney over time.
Using this information, researchers found that 47 percent of patients had minimal fibrosis (scarring) and 40 percent had mild fibrosis (87 percent total) one year after transplant. At five years after transplant, the numbers changed slightly, with 38 percent showing minimal fibrosis and 45 percent showing mild fibrosis (83 percent total). Results were similar for kidneys transplanted from living and deceased donors.
Dr. Stegall explains that minimal or mild fibrosis does not interfere significantly with kidney function. However, the development of severe scarring interferes with the kidney's ability to function and may result in the patient needing to start dialysis or undergo a second transplant.
Key to the study was that biopsies were routinely taken at post-transplant checkups. "That information allowed us to better understand what happens over those five years," says Walter Park, Mayo Clinic associate in the Department of Surgery (http://www.mayoclinic.org/surgery/) who analyzed the study data. "We now know that when patients have mild fibrosis at one year, it doesn't mean that it will progress to severe fibrosis at five years."
The research team will continue its work to learn more about why some kidneys still develop problems and how to avoid them. They also are interested in determining if kidneys that are doing well at five years are still prone to injury later.
VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. Mark Stegall, are available on the Mayo Clinic News Blog (http://dev.newsblog.mayoclinic.org/2011/04/07/kidney-transplant-study/).
Mayo Clinic in Rochester is one of the largest kidney transplant centers in the United States. In 2010, Mayo Clinic surgeons provided 198 patients with transplanted kidneys; 144 of those were from living donors.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit www.mayoclinic.org/about/ and www.mayoclinic.org/news.
Ginger Plumbo | EurekAlert!
Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung
High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences