While epilepsy surgery is a safe and effective intervention for seizure control, medical therapy remains the more prominent treatment option for those with epilepsy.
However, a new 26-year study reveals that following epilepsy surgery, nearly half of participants were free of disabling seizures and 80% reported better quality of life than before surgery. Findings from this study—the largest long-term study to date—are now available in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE).
More than 50 million individuals worldwide suffer from seizures caused by epilepsy according to a 2001 report by the World Health Organization (WHO). Medical evidence shows that compared with the general population, epilepsy patients have significantly poorer health-related quality of life, higher rates of co-morbidites, and lower rates of employment, marriage, and education levels. Previous studies found that while a majority of those with epilepsy do respond to antiepileptic drugs, over 30% patients are refractory to medical therapy.
"In cases where medical therapy fails to control seizures, epilepsy surgery is a safe and effective treatment option," explains lead author Dr. Matthew Smyth with Washington University School of Medicine in St. Louis, Missouri. "Despite the increase in the number of epilepsy surgeries performed, and reports in the medical literature of the success of surgery relative to medication, it remains an underutilized therapy for seizure control." A 2001 study estimated that less than 0.1% of the more than 4 million people worldwide who could benefit from epilepsy surgery actually receive the intervention.
To advance understanding of long-term seizure control rates, researchers analyzed data of seizure and quality of life outcomes for 361 patients who underwent epilepsy surgery between 1967 and 1990; Dr. Sidney Goldring, a prominent neurosurgeon and pioneer of epilepsy surgery, performed the procedures. Patients were then surveyed to assess seizure control and quality of life.
Of the 361 patients, 117 completed follow-up interviews for the study and 48% were determined to be free of disabling seizures. On a survey assessing the quality of life for those with epilepsy, 80% of patients reported their overall quality life was better than before the surgery. As the authors expected, surgical complications and mortality following surgery declined over the long-term. No statistically significant association between postoperative complications and long-term seizure control or quality of life outcomes was observed.
"Our findings demonstrate that the benefits of epilepsy surgery are sustained over long time periods," concludes Dr. Smyth. "Increased use of surgical intervention offers patients with epilepsy the possibility of long-term seizure control and improved quality of life."
This study is published in Epilepsia. Media wishing to receive a PDF of this article may contact firstname.lastname@example.org.Full citation:"Impact of Epilepsy Surgery on Seizure Control and Quality of Life: A 26-year Follow-up Study." Hussan S. Mohammed, Christian B. Kaufman, David D. Limbrick, Karen Steger-May, Robert L. Grubb Jr., Steven M. Rothman, Judy Weisenberg, Rebecca Munro, Matthew D. Smyth. Epilepsia; February 7, 2012 (DOI:10.1111/j.1528-1167.2011.03398.x).
Epilepsia is the leading, most authoritative source for current clinical and research results on all aspects of epilepsy. As the journal of the International League Against Epilepsy, subscribers every month will review scientific evidence and clinical methodology in: clinical neurology, neurophysiology, molecular biology, neuroimaging, neurochemistry, neurosurgery, pharmacology, neuroepidemiology, and therapeutic trials. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1528-1167.
The International League Against Epilepsy (ILAE) is the world's preeminent association of physicians and health professionals working toward a world where no person's life is limited by epilepsy. Since 1909 the ILAE has provided educational and research resources that are essential in understanding, diagnosing and treating persons with epilepsy. The ILAE supports health professionals, patients, and their care providers, governments, and the general public worldwide by advancing knowledge of epilepsy. For information about ILAE, please visit http://www.ilae.org/.
Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit http://www.wileyblackwell.com or our new online platform, Wiley Online Library (http://www.wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.
Dawn Peters | EurekAlert!
Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung
Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences