"Substances that appear at first glance to be harmless can cause allergic reactions since skin enzymes may help to form new, allergenic substances from them, giving rise to dermatitis and other skin problems. This is the case for isothiocyanates, which are formed on the skin following repeated contact with rubber", says Kristin Samuelsson of the Department of Chemistry at the University of Gothenburg.
Around one in five adults in Europe suffers from contact allergy against one or several chemical substances to which they are exposed. The most common allergy is against nickel, while many people suffer from contact allergy against, for example, perfume. A substance must bind to proteins in the skin before it can give rise to an allergy. This means that substances must be chemically reactive, if they are to cause an allergic reaction. Isothiocyanates are potent contact allergens that occur naturally in vegetables. They are used also in technical products.
Kristin Samuelsson has used fluorescent isothiocyanates to study how allergenic substances are absorbed by the skin and lymph nodes, after being applied to the skin. The results show that the reactive isothiocyanates are mainly restricted to the outermost layer of skin (known as the "stratum corneum"), which consists of dead cells. Even so, the isothiocyanates that were tested were potent allergens.
Diphenylthiourea is a substance that is used in the production of rubber, including the neoprene rubber that is used in mouse mats, wetsuits, knee protectors and other products with which we have close and frequent contact. Isothiocyanates are among the substances that are formed from diphenylthiourea when it is applied to skin.
The number of patients with reported allergies against neoprene rubber is not actually very high, but this may be because it is difficult to confirm such allergies. The results presented in the thesis have led to the initiation of a new study at the Skin Clinic, Sahlgrenska University Hospital, in which patients with suspected allergy against neoprene rubber will be tested using the isothiocyanate that is formed in the skin. Testing with the active allergen increases the chances of detecting cases of rubber allergy, and thus providing the appropriate treatment and advice for the patients. Identifying allergenic substances in common products will also make it possible to reduce the exposure of the general population to such substances.
The thesis: Isothiocyanates as skin sensitizers. Bioactivation and distributor in skin and draining lymph nodes has been successfully defended.
Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena
Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
21.07.2017 | Earth Sciences
21.07.2017 | Power and Electrical Engineering
21.07.2017 | Physics and Astronomy