Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Knee pain common complaint in middle-aged and mature women

19.12.2011
Study finds pain patterns vary over a 12-year period

New research shows 63% of women age 50 and older reported persistent, incident, or intermittent knee pain during a 12-year study period. Predictors for persistent pain included higher body mass index (BMI), previous knee injury, and radiographic osteoarthritis (OA). Details of this longitudinal study are available in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR).

According to the ACR more than 27 million Americans over age 25 suffer from OA—a leading cause of disability worldwide—with pain being the most problematic symptom for patients. The economic burden from OA is substantial, with reports estimating the U.K. annual loss of productivity cost at £3.2 billion. In the U.S., the Centers for Disease Control and Prevention (CDC) estimates job-related OA costs $3.4 to $13.2 billion per year. Prior studies suggest knee OA, specifically, is associated with impaired physical function and substantial societal burden. In fact, the CDC reported close to 500,000 total knee replacements were performed in the U.S. in 2004 with more than $14 billion spent on hospital costs related to the procedure.

"Our study is the first community-based investigation of knee pain patterns using multiple assessment points over a 12-year period," explains lead author Nigel Arden, MSc, MD, a Professor of Rheumatology at the University of Oxford in the UK. "Understanding the prevalence and predictors of knee pain is the first step in developing comprehensive pain assessment plans that could lead to more targeted treatment options for those burdened by OA."

For the present study, researchers used data obtained from participants of the Chingford Study, a prospective population-based study of OA and osteoporosis established in 1989. More than 1,000 women between the ages of 44 and 57 years (median age of 52 years) participated, and were representative of women in the U.K. general population in terms of weight, height and smoking characteristics. At the end of the 12-year study, data relating to self-reported knee pain was analyzed and used to classify the 489 remaining participants into four pain groups—asymptomatic, persistent, incident, and intermittent.

The team found a prevalence of 44% for "any days of pain" and 23% for "pain on most days of the previous month" in the cohort at the end of the study period. Of those experiencing "any pain" versus "pain on most days," 9% and 2% had persistent pain; 24% and 16% had incident pain; and 29% and 18% had intermittent pain, respectively. Researchers determined that a higher BMI predicted persistent and incident pain patterns, while radiographic OA was a predictor of persistent pain. Those reporting knee injury were likely to have persistent or intermittent pain patterns.

The authors suggest a primary strength of this study is that it describes the natural history of knee pain over a long-term period and incorporates data from multiple time points. Study findings confirm the presence of variable pain patterns, with few women consistently reporting knee pain at each measurement time point. Professor Arden concludes, "Validation of our findings through reproduction in other patient groups is needed to advance knowledge of knee pain predictors that will ultimately enhance prevention and treatment strategies for those with OA."

This study is published in Arthritis & Rheumatism. Media wishing to receive a PDF of the article may contact healthnews@wiley.com.

Full citation:

"Self-Reported Knee Pain Prevalence in a Community-Based Cohort Over 12 Years." A. Soni, A. Kiran, D. Hart, K. M. Leyland, L. Goulston, C. Cooper, M. K. Javaid, T. D. Spector, N. K. Arden. Arthritis & Rheumatism; Published Online: December 19, 2011 (DOI: 10.1002/art.33434).

Author Contact: To arrange an interview with Professor Arden, please contact Jonathan Wood with the University of Oxford at jonathan.wood@admin.ox.ac.uk or 44-1865-280530.

About the Journal

Arthritis & Rheumatism is an official journal of the American College of Rheumatology (ACR) and the Association of Rheumatology Health Professionals (ARHP), a division of the College, and covers all aspects of inflammatory disease. The American College of Rheumatology (http://www.rheumatology.org) is the professional organization who share a dedication to healing, preventing disability, and curing the more than 100 types of arthritis and related disabling and sometimes fatal disorders of the joints, muscles, and bones. Members include practicing physicians, research scientists, nurses, physical and occupational therapists, psychologists, and social workers. For details, please visit http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1529-0131.

About Wiley-Blackwell

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit http://www.wileyblackwell.com or our new online platform, Wiley Online Library (http://www.wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

Dawn Peters | Wiley-Blackwell
Further information:
http://www.wiley.com

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>