Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

IU study examines how genes, gender and environment influence substance abuse

18.08.2014

Social integration, including strong family ties, can protect one's well-being and even reduce the impact high-risk genes have on health. Scientists call this phenomenon a gene-environment interaction. An Indiana University study focusing on substance abuse, however, found that a three-way interplay of gender, genetics and social integration produced the different outcomes for men and women.

The study looked at men and women with a genetic sensitivity to stressful situations. Strong family and community ties were protective for such men, reducing their risk of abusing alcohol and drugs or using tobacco; but for women with the same genetic sensitivity, the costs associated with strong social ties could outweigh the benefits.

Clinicians and researchers have known for decades that gender shapes the kinds of risks and protections people are exposed to in everyday life, causing men and women to experience different types of health problems. The study by medical sociologist Brea Perry is unique because it adds the genetic dimension.

"It is likely that gene-environment interactions may operate differently for men and women, perhaps because they experience some aspects of the social world in divergent ways," Perry said. "In families and communities, for example, women often bear more responsibility for developing and maintaining relationships, and do more of the care work that is required in those contexts. We cannot assume that a social environment that is favorable for men, and thus reduces the harmful impact of a risky genotype, is also beneficial for women, or vice versa."

She is discussing her findings at 8:30 a.m. Monday at the American Sociological Association's annual meeting in San Francisco.

Perry's study used data from the Collaborative Study on the Genetics of Alcoholism, a study funded by the National Institutes of Health to map genes associated with alcohol dependence and related patterns of substance abuse and behavior. The sample of participants in her analysis included 4,307 adults from 1,026 families. Some of the participants had substance dependence, but not all did. She targeted the GABRA2 gene, which is related to increased risk for substance use disorders through sensitivity to stressful or emotionally charged social environments.

Social integration can help those who struggle with substance abuse, particularly men who are in need of additional emotional support and strong bonds to keep them from engaging in excessive drinking or drug use. For women, ties to family and community are positive for most, but the demands of relationships may be overwhelming for women with a sensitivity to stress. According to Perry, these women would likely benefit from a stronger social services safety net, including programs that shift some of the responsibility for care work off their shoulders. Such programs might include government-subsidized child care or in-home health workers for those with ill or elderly relatives.

Research indicates that social and biological factors interact in very complex ways to shape health and well-being, and gender may complicate this picture even further. However, the potential impact of this kind of research on our understanding of how and why certain groups are more or less susceptible to physical and mental health problems is substantial.

"It is quite likely that any heritable health condition that is influenced by social factors, such as obesity, cardiovascular disease and depression, might exhibit gender-specific gene-environment interactions," Perry said.

But it also points to the complexity of disease and health behavior.

###

The study was supported by the Peter F. McManus Charitable Trust.

Perry can be reached at blperry@indiana.edu or 812-856-0447. For additional assistance, contact Tracy James at 812-855-0084 or traljame@iu.edu.

Brea Perry | Eurek Alert!

Further reports about: alcohol dependence factors families genes problems sensitivity stressful

More articles from Studies and Analyses:

nachricht High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg

nachricht Brain connectivity reveals hidden motives
04.03.2016 | Universität Zürich

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Optical lenses, hardly larger than a human hair

3D printing enables the smalles complex micro-objectives

3D printing revolutionized the manufacturing of complex shapes in the last few years. Using additive depositing of materials, where individual dots or lines...

Im Focus: Flexible OLED applications arrive

R2D2, a joint project to analyze and development high-TRL processes and technologies for manufacture of flexible organic light-emitting diodes (OLEDs) funded by the German Federal Ministry of Education and Research (BMBF) has been successfully completed.

In contrast to point light sources like LEDs made of inorganic semiconductor crystals, organic light-emitting diodes (OLEDs) are light-emitting surfaces. Their...

Im Focus: Unexpected flexibility found in odorant molecules

High resolution rotational spectroscopy reveals an unprecedented number of conformations of an odorant molecule – a new world record!

In a recent publication in the journal Physical Chemistry Chemical Physics, researchers from the Max Planck Institute for the Structure and Dynamics of Matter...

Im Focus: 3-D printing produces cartilage from strands of bioink

Strands of cow cartilage substitute for ink in a 3D bioprinting process that may one day create cartilage patches for worn out joints, according to a team of engineers. "Our goal is to create tissue that can be used to replace large amounts of worn out tissue or design patches," said Ibrahim T. Ozbolat, associate professor of engineering science and mechanics. "Those who have osteoarthritis in their joints suffer a lot. We need a new alternative treatment for this."

Cartilage is a good tissue to target for scale-up bioprinting because it is made up of only one cell type and has no blood vessels within the tissue. It is...

Im Focus: First experimental quantum simulation of particle physics phenomena

Physicists in Innsbruck have realized the first quantum simulation of lattice gauge theories, building a bridge between high-energy theory and atomic physics. In the journal Nature, Rainer Blatt‘s and Peter Zoller’s research teams describe how they simulated the creation of elementary particle pairs out of the vacuum by using a quantum computer.

Elementary particles are the fundamental buildings blocks of matter, and their properties are described by the Standard Model of particle physics. The...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Conference ‘GEO BON’ Wants to Close Knowledge Gaps in Global Biodiversity

28.06.2016 | Event News

ERES 2016: The largest conference in the European real estate industry

09.06.2016 | Event News

Networking 4.0: International Laser Technology Congress AKL’16 Shows New Ways of Cooperations

24.05.2016 | Event News

 
Latest News

Building a better battery

29.06.2016 | Life Sciences

New way out: Researchers show how stem cells exit bloodstream

29.06.2016 | Life Sciences

Crucial peatlands carbon-sink vulnerable to rising sea levels

29.06.2016 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>