Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

IU study examines how genes, gender and environment influence substance abuse

18.08.2014

Social integration, including strong family ties, can protect one's well-being and even reduce the impact high-risk genes have on health. Scientists call this phenomenon a gene-environment interaction. An Indiana University study focusing on substance abuse, however, found that a three-way interplay of gender, genetics and social integration produced the different outcomes for men and women.

The study looked at men and women with a genetic sensitivity to stressful situations. Strong family and community ties were protective for such men, reducing their risk of abusing alcohol and drugs or using tobacco; but for women with the same genetic sensitivity, the costs associated with strong social ties could outweigh the benefits.

Clinicians and researchers have known for decades that gender shapes the kinds of risks and protections people are exposed to in everyday life, causing men and women to experience different types of health problems. The study by medical sociologist Brea Perry is unique because it adds the genetic dimension.

"It is likely that gene-environment interactions may operate differently for men and women, perhaps because they experience some aspects of the social world in divergent ways," Perry said. "In families and communities, for example, women often bear more responsibility for developing and maintaining relationships, and do more of the care work that is required in those contexts. We cannot assume that a social environment that is favorable for men, and thus reduces the harmful impact of a risky genotype, is also beneficial for women, or vice versa."

She is discussing her findings at 8:30 a.m. Monday at the American Sociological Association's annual meeting in San Francisco.

Perry's study used data from the Collaborative Study on the Genetics of Alcoholism, a study funded by the National Institutes of Health to map genes associated with alcohol dependence and related patterns of substance abuse and behavior. The sample of participants in her analysis included 4,307 adults from 1,026 families. Some of the participants had substance dependence, but not all did. She targeted the GABRA2 gene, which is related to increased risk for substance use disorders through sensitivity to stressful or emotionally charged social environments.

Social integration can help those who struggle with substance abuse, particularly men who are in need of additional emotional support and strong bonds to keep them from engaging in excessive drinking or drug use. For women, ties to family and community are positive for most, but the demands of relationships may be overwhelming for women with a sensitivity to stress. According to Perry, these women would likely benefit from a stronger social services safety net, including programs that shift some of the responsibility for care work off their shoulders. Such programs might include government-subsidized child care or in-home health workers for those with ill or elderly relatives.

Research indicates that social and biological factors interact in very complex ways to shape health and well-being, and gender may complicate this picture even further. However, the potential impact of this kind of research on our understanding of how and why certain groups are more or less susceptible to physical and mental health problems is substantial.

"It is quite likely that any heritable health condition that is influenced by social factors, such as obesity, cardiovascular disease and depression, might exhibit gender-specific gene-environment interactions," Perry said.

But it also points to the complexity of disease and health behavior.

###

The study was supported by the Peter F. McManus Charitable Trust.

Perry can be reached at blperry@indiana.edu or 812-856-0447. For additional assistance, contact Tracy James at 812-855-0084 or traljame@iu.edu.

Brea Perry | Eurek Alert!

Further reports about: alcohol dependence factors families genes problems sensitivity stressful

More articles from Studies and Analyses:

nachricht Researchers observe major hand hygiene problems in operating rooms
30.03.2015 | University of Gothenburg

nachricht Electric vehicle range in 450,000 kilometer real-world test
30.03.2015 | Technische Universität Chemnitz

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Experiment Provides the Best Look Yet at 'Warm Dense Matter' at Cores of Giant Planets

In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...

Im Focus: Energy-autonomous and wireless monitoring protects marine gearboxes

The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.

As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...

Im Focus: 3-D satellite, GPS earthquake maps isolate impacts in real time

Method produced by UI researcher could improve reaction time to deadly, expensive quakes

When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.

Im Focus: Atlantic Ocean overturning found to slow down already today

The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe. 

Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...

Im Focus: Robot inspects concrete garage floors and bridge roadways for damage

Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.

From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Conference On Regenerative Medicine 2015: Registration And Abstract Submission Now Open

25.03.2015 | Event News

University presidents from all over the world meet in Hamburg

19.03.2015 | Event News

10. CeBiTec Symposium zum Big Data-Problem

17.03.2015 | Event News

 
Latest News

Travelling pollution – East Asian human activities affect air quality in remote tropical forests

31.03.2015 | Earth Sciences

Why there was a sudden diversification of species

31.03.2015 | Earth Sciences

Speech dynamics are coded in the left motor cortex

31.03.2015 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>