The research is published in the February issue of the journal Diabetes Care and is available online.
Patients with diabetes, particularly women, have a substantial increased risk of dying from ischemic heart disease, according to previous research. However, future cardiac events may be prevented with intensive glycemic control.
In the current longitudinal study, UIC researchers looked at changes over time in carotid intima-media thickness, or CIMT -- a marker for atherosclerosis -- in a group of type 1 diabetes patients without kidney disease or previous cardiovascular events.
"This is the first study to look at what happens to diabetes-related cardiovascular complications after islet cell transplantation alone without kidney transplant," said Kirstie Danielson, assistant professor in the UIC College of Medicine and School of Public Health, and lead author of the study, who noted that previous research has focused on metabolic changes and glycemic control after transplant.
The 15 adults (two men and 13 women) suffered from type 1 diabetes for more than five years and had hypoglycemic unawareness despite best efforts to manage insulin levels. The patients received a total of 27 islet transplants (one to three transplants each) and were followed from one to five years after their first transplant. CIMT was measured before and approximately every 12 months after the first islet transplant.
The researchers found a significant decrease in CIMT one year after islet transplant. The CIMT measures started to progress again -- slightly more than they would in healthy individuals without diabetes -- between 12 and 50 months. At 50 months, post-transplant the CIMT measures were still lower than pre-transplant levels, Danielson said.
"The decline of CIMT we saw at one year is not generally seen in patients with diabetes," said Danielson, who attributes the improvements to better glycemic control achieved through islet transplantation and better management of cholesterol, or lipid levels, post-transplant.
All 15 patients achieved insulin independence after receiving one to three islet transplants at the University of Illinois Hospital & Health Sciences System. At the end of the current study, 11 patients were insulin free, three remained on insulin but at greatly reduced doses, and one patient withdrew from the trial because of islet graft loss.
The next step would be to replicate these results in a larger trial, Danielson said.
Co-authors include Dr. Jose Oberholzer, Dr. Enrico Benedetti, Dr. Alessandra Mele, Dr. Meirigeng Qi, Joan Martellotto and Katie Kinzer from the UIC College of Medicine, Dr. Betul Hatipoglu from the Clevelend Clinic, and Dr. Bruce Kaplan from the University of Arizona.
The University of Illinois Hospital & Health Sciences System provides comprehensive care, education and research to the people of Illinois and beyond. The UI Health System includes a 495-bed tertiary hospital; the University of Illinois at Chicago Colleges of Medicine, Dentistry, Pharmacy, Nursing, Applied Health Sciences, School of Public Health and the Jane Addams College of Social Work; 22 outpatient clinics located in Chicago; 12 federally qualified health centers throughout the city; and Colleges of Medicine and affiliated health care facilities in Urbana, Peoria and Rockford.
For more information: The University of Illinois Hospital & Health Sciences System.
Sherri McGinnis González | EurekAlert!
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
26.04.2017 | Materials Sciences
26.04.2017 | Agricultural and Forestry Science
26.04.2017 | Physics and Astronomy