Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Islet transplant may slow progression of atherosclerosis

29.01.2013
Minimally invasive islet transplantation for patients with type 1 diabetes achieves insulin independence and reverses the progression of atherosclerosis in the first few years after transplant, according to a University of Illinois at Chicago study.

The research is published in the February issue of the journal Diabetes Care and is available online.

Patients with diabetes, particularly women, have a substantial increased risk of dying from ischemic heart disease, according to previous research. However, future cardiac events may be prevented with intensive glycemic control.

In the current longitudinal study, UIC researchers looked at changes over time in carotid intima-media thickness, or CIMT -- a marker for atherosclerosis -- in a group of type 1 diabetes patients without kidney disease or previous cardiovascular events.

"This is the first study to look at what happens to diabetes-related cardiovascular complications after islet cell transplantation alone without kidney transplant," said Kirstie Danielson, assistant professor in the UIC College of Medicine and School of Public Health, and lead author of the study, who noted that previous research has focused on metabolic changes and glycemic control after transplant.

The 15 adults (two men and 13 women) suffered from type 1 diabetes for more than five years and had hypoglycemic unawareness despite best efforts to manage insulin levels. The patients received a total of 27 islet transplants (one to three transplants each) and were followed from one to five years after their first transplant. CIMT was measured before and approximately every 12 months after the first islet transplant.

The researchers found a significant decrease in CIMT one year after islet transplant. The CIMT measures started to progress again -- slightly more than they would in healthy individuals without diabetes -- between 12 and 50 months. At 50 months, post-transplant the CIMT measures were still lower than pre-transplant levels, Danielson said.

"The decline of CIMT we saw at one year is not generally seen in patients with diabetes," said Danielson, who attributes the improvements to better glycemic control achieved through islet transplantation and better management of cholesterol, or lipid levels, post-transplant.

All 15 patients achieved insulin independence after receiving one to three islet transplants at the University of Illinois Hospital & Health Sciences System. At the end of the current study, 11 patients were insulin free, three remained on insulin but at greatly reduced doses, and one patient withdrew from the trial because of islet graft loss.

The next step would be to replicate these results in a larger trial, Danielson said.

Co-authors include Dr. Jose Oberholzer, Dr. Enrico Benedetti, Dr. Alessandra Mele, Dr. Meirigeng Qi, Joan Martellotto and Katie Kinzer from the UIC College of Medicine, Dr. Betul Hatipoglu from the Clevelend Clinic, and Dr. Bruce Kaplan from the University of Arizona.

The University of Illinois Hospital & Health Sciences System provides comprehensive care, education and research to the people of Illinois and beyond. The UI Health System includes a 495-bed tertiary hospital; the University of Illinois at Chicago Colleges of Medicine, Dentistry, Pharmacy, Nursing, Applied Health Sciences, School of Public Health and the Jane Addams College of Social Work; 22 outpatient clinics located in Chicago; 12 federally qualified health centers throughout the city; and Colleges of Medicine and affiliated health care facilities in Urbana, Peoria and Rockford.

For more information: The University of Illinois Hospital & Health Sciences System.

Sherri McGinnis González | EurekAlert!
Further information:
http://www.uic.edu

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>