Their hypothesis – that increasing the normally occurring process of making nerve cells might prevent addiction – is based on a rodent study demonstrating that blocking new growth of specific brain nerve cells increases vulnerability for cocaine addiction and relapse.
The study's findings, available in the Journal of Neuroscience, are the first to directly link addiction with the process, called neurogenesis, in the region of the brain called the hippocampus.
While the research specifically focused on what happens when neurogenesis is blocked, the scientists said the results suggest that increasing adult neurogenesis might be a potential way to combat drug addiction and relapse.
"More research will be needed to test this hypothesis, but treatments that increase adult neurogenesis may prevent addiction before it starts, which would be especially important for patients treated with potentially addictive medications," said Dr. Amelia Eisch, associate professor of psychiatry at UT Southwestern and senior author of the study. "Additionally, treatments that increase adult neurogenesis during abstinence might prevent relapse."
Increasingly, addiction researchers have recognized that some aspects of the condition – such as forming drug-context associations – might involve the hippocampus, which is a region of the brain associated with learning and memory. Only with recent technological advances have scientists been able to test their theories in animals by manipulating the birth of new nerve cells in the hippocampus of the adult brain.
Physical activity and novel and enriched environments have been shown in animal studies to be good for the brain in general, but more research is needed to see if they can increase human adult neurogenesis.
Dr. Eisch and her colleagues used advanced radiation delivery techniques to prevent hippocampal neurogenesis. In one experiment, rats were allowed to self-administer cocaine by pressing a lever. Rats with radiated brains took more cocaine and seemed to find it more rewarding than rats that did not receive radiation.
In a second experiment, rats first self-administered cocaine and then received radiation to decrease neurogenesis during a period of time that they were without drugs. Rats with reduced neurogenesis took more time to realize that a drug lever was no longer connected to the drug dispenser.
"The nonirradiated rats didn't like the cocaine as much and learned faster to not press the formerly drug-associated lever," Dr. Eisch said. "In the context of this experiment, decreased neurogenesis fueled the process of addiction, instead of the cocaine changing the brain."
Dr. Eisch said she plans to do similar studies with other drugs of abuse, using imaging technology to study addiction and hippocampal neurogenesis in humans.
"If we can create and implement therapies that prevent addiction from happening in the first place, we can improve the length and quality of life for millions of drug abusers, and all those affected by an abuser's behavior," she said.
Another study author from UT Southwestern was Sarah Bulin, a graduate student research assistant. Other researchers involved in the work include Dr. Michele Noonan, former graduate research assistant in psychiatry, and Dwain Fuller from the VA North Texas Health Care System.
The study was funded by the National Institute on Drug Abuse.
Visit http://www.utsouthwestern.org/neurosciences to learn more about UT Southwestern's clinical services in the neurosciences, including psychiatry.
This news release is available on our World Wide Web home page at http://www.utsouthwestern.edu/home/news/index.html
To automatically receive news releases from UT Southwestern via e-mail, subscribe at www.utsouthwestern.edu/receivenews
LaKisha Ladson | EurekAlert!
The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig
Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
23.11.2017 | Information Technology
23.11.2017 | Physics and Astronomy
23.11.2017 | Life Sciences