Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Important defence against stomach ulcer bacterium identified

12.10.2009
A special protein in the lining of the stomach has been shown to be an important part of the body's defence against the stomach ulcer bacterium Helicobacter pylori in a new study from the Sahlgrenska Academy at the University of Gothenburg. The discovery may explain why the bacterium makes some people more ill than others.

The study was conducted in collaboration with researchers at universities in Brisbane and Melbourne and has been published in the scientific journal Public Library of Science Pathogens.

"Half of all people carry Helicobacter pylori in their bodies," says Sara Lindén from the Sahlgrenska Academy, one of the researchers behind the study. "Many don't even notice that they have the bacterium, but some develop stomach ulcers, and in some cases the inflammation leads to stomach cancer. Our discovery may partially explain why the bacterium affects people so differently."

The research team has shown that a protein called MUC1 found in the lining of the stomach is important for the body's defence against the bacterium. Greatly magnified, MUC1 looks like a tree growing out of low bushes on the surface of the stomach. As MUC1 is taller than the other structures on the cell surface, Helicobacter pylori readily becomes attached to the protein and then rarely gets to infect the cell.

"You could say that MUC1 acts as a decoy which prevents the bacterium from coming into close contact with the cell surface," says Lindén. "Genetic variations between people mean that our MUC1 molecules vary in length, and this may be part of the reason why Helicobacter pylori makes some people more ill than others."

The Research team of Sara Lindén is located at the Sahlgrenska Academy's strategic research centre MIVAC (Mucosal Immunobiology and Vaccine Center). Researchers at the centre are developing new ways of treating diseases that affect the mucus membranes.

ABOUT HELICOBACTER PYLORI
There are many different strains of the helical rod bacterium Helicobacter pylori. The bacterium has several different structures on its surface that it uses to attach to other structures rather like a space shuttle docks onto a space station. These structures look different on different strains of the bacterium.
For more information, please contact:
Sara Lindén, assistant professor, tel +46 70 981 79 79, +46 584 47 20 27, e-mail sara.linden@gu.se
Journal: Public Library of Science Pathogens
Title of article: MUC1 Limits Helicobacter pylori Infection Both by Steric Hindrance and by Acting as a Releasable Decoy

Authors: Sara K Lindén, Yong H Sheng, Alison L Every, Kim M Miles, Emma C Skoog, Timothy HJ Florin, Philip Sutton and Michael A McGuckin

Elin Lindström Claessen
Public Relations Officer at the Sahlgrenska Academy at the University of Gothenburg
Tel: +46 31 786 3869, +46 70 829 43 03
E-mail: elin.lindstrom@sahlgrenska.gu.se
The Sahlgrenska Academy is the health sciences faculty at the University of Gothenburg and conducts education and research in the fields of medicine, dentistry and care sciences. About 4,000 undergraduate and 1,000 doctoral students are enrolled at the academy, which has 1,500 employees, including 850 research and/or teaching staff.

Helena Aaberg | idw
Further information:
http://www.gu.se/
http://www.sahlgrenska.gu.se

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>