New research shows that febrile seizures in children may be linked to respiratory alkalosis, indicated by elevated blood pH and low carbon dioxide levels caused by hyperventilation, and independent of the underlying infection severity.
Febrile seizures were not observed in susceptible children with fevers brought on by gastroenteritis, suggesting that low blood pH levels (acidosis) may have a protective effect. Full findings now appear in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE).
Febrile seizures are the most common type of convulsive disorder in children, affecting nearly 1 out of every 25 children and typically occurring between the ages of 6 months and 5 years, according to the National Institute of Neurological Disorders and Stroke (NINDS). Previous studies have suggested that a combination of genetic and environmental factors cause febrile seizures which have an incidence of up to 8% depending on geographical region and culture.
To further understand the functional changes associated with febrile seizures, a team of investigators, led by Dr. Sebastian Schuchmann, at the Charité-Universitätsmedizin Berlin in Germany and the University of Helsinki in Finland enrolled and analysed 433 children with similar fever levels who were admitted to hospital for febrile seizure (n=213) or gastroenteritis (n=220). All pediatric patients had their blood pH and carbon dioxide levels measured upon admission.
Researchers found respiratory alkalosis in children with febrile seizures and metabolic acidosis in pediatric patients admitted for gastroenteritis. Febrile seizures did not occur in children with gastroenteritis, except in a subgroup of 15 patients who had an alkaline blood pH level. Additionally, 8 patients were admitted on separate occasions for febrile seizures and gastroenteritis; blood pH was elevated when the child was admitted with febrile seizure, but a more acidotic pH was found when the child presented with gastroenteritis.
"Our findings reveal that febrile seizures are associated with respiratory alkalosis and unrelated to the severity of the underlying infection or fever level," concluded Dr. Schuchmann. "Further investigation of methods that control the body's acid-base status may lead to the development of novel therapies for treating febrile seizures." Based on the study results, the authors suggest an application of 5% carbon dioxide in the breathing air as a possible treatment for febrile seizures.
This study is published in Epilepsia. Media wishing to receive a PDF of this article may contact firstname.lastname@example.org.
Full citation:"Respiratory Alkalosis in Children with Febrile Seizures." Sebastian Schuchmann, Sarah Hauck, Stephan Henning, Annette Grüters-Kieslich, Sampsa Vanhatalo, Dietmar Schmitz, Kai Kaila. Epilepsia; Published Online: September 12, 2011 (DOI: 10.1111/j.1528-1167.2011.03259.x). http://doi.wiley.com/10.1111/j.1528-1167.2011.03259.x
Epilepsia is the leading, most authoritative source for current clinical and research results on all aspects of epilepsy. As the journal of the International League Against Epilepsy, subscribers every month will review scientific evidence and clinical methodology in: clinical neurology, neurophysiology, molecular biology, neuroimaging, neurochemistry, neurosurgery, pharmacology, neuroepidemiology, and therapeutic trials. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1528-1167.
Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.
Dawn Peters | EurekAlert!
Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
18.06.2018 | Earth Sciences
18.06.2018 | Process Engineering
18.06.2018 | Life Sciences