Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Henry Ford study links 23 microRNAs to laryngeal cancer

14.09.2011
A Henry Ford Hospital study has identified 23 microRNAs for laryngeal cancer, a discovery that could yield new insight into what causes certain cells to grow and become cancerous tumors in the voice box.

The role of microRNA (miRNA), the small, non-coding RNA molecules that regulate human genes, has recently come into greater focus as researchers continue to understand the cellular mechanics of cancer development, says Kang Mei Chen, M.D., the study's lead author.

"While they may be small, miRNAs are no longer being viewed as just molecular noise," says Dr. Chen, a research investigator in the Department of Otolaryngology – Head & Neck Surgery at Henry Ford Hospital.

"We now recognize miRNAs as bigger players with increasing prominence in theories about cancer."

Findings from the Henry Ford study – supported by a NIH grant – will be presented Tuesday, Sept. 13 in San Francisco at the American Academy of Otolaryngology–Head & Neck Surgery Foundation Annual Meeting.

MiRNA may help cancer researchers unravel the complexities of what happens at the genomic level of cell evolution. It's estimated that there are at least 800 human miRNAs.

Since miRNAs are differentially expressed in various types of cancers compared with noncancerous tissues, researchers believe that they may play a crucial role in the production or formation of tumors.

"By gaining insight into laryngeal cancer, it gives us another level to understand what goes wrong and when cells decide to embark on a tumor genesis journey. From there, it's possible for researchers to look at how to control cancer growth and improve treatment," says co-author Maria J. Worsham, Ph.D., director of research in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

The goal of the Henry Ford study was to discover miRNAs specific to laryngeal squamous cell carcinoma – a form of head and neck cancer that starts in the voice box.

Led by Dr. Chen, the researchers performed global miRNA profiling on stored laryngeal squamous cell carcinoma samples, as well as non-cancerous tissue samples from the larynx.

The team then used quantitative real-time polymerase chain reaction – a fast and inexpensive technique used to copy small segments of DNA – to verify miRNAs in the laryngeal cancer samples.

Of the 800 human miRNAs, 23 were found to be different between the cancerous and normal laryngeal tissue samples.

Among the 23 miRNAs tied to laryngeal cancer through the Henry Ford study, 15 had yet to be reported in head and neck cancer.

With the field narrowed to 23 miRNAs in laryngeal cancer, it presents researchers with the opportunity to quantify each piece of RNA and further study miRNAs in head and neck cancer, notes Dr. Chen.

The NIH-funded head and neck squamous carcinoma cohort for Detroit, with over 1,000 primary patients, includes more than 200 laryngeal sites, giving Henry Ford researchers the opportunity to look at miRNA expression in a larger group of laryngeal cancers as well as in other head and neck cancer sites.

Along with Drs. Chen and Worsham, study co-authors from Henry Ford are Josena K. Stephen, M.D.; Shaleta Havard; Veena Shah, M.D.; Glendon Gardner, M.D.; and Vanessa G. Schweitzer, M.D.

Research Support: NIH grant R01DE15990.

Krista Hopson | EurekAlert!
Further information:
http://www.hfhs.org

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>