Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Henry Ford study links 23 microRNAs to laryngeal cancer

14.09.2011
A Henry Ford Hospital study has identified 23 microRNAs for laryngeal cancer, a discovery that could yield new insight into what causes certain cells to grow and become cancerous tumors in the voice box.

The role of microRNA (miRNA), the small, non-coding RNA molecules that regulate human genes, has recently come into greater focus as researchers continue to understand the cellular mechanics of cancer development, says Kang Mei Chen, M.D., the study's lead author.

"While they may be small, miRNAs are no longer being viewed as just molecular noise," says Dr. Chen, a research investigator in the Department of Otolaryngology – Head & Neck Surgery at Henry Ford Hospital.

"We now recognize miRNAs as bigger players with increasing prominence in theories about cancer."

Findings from the Henry Ford study – supported by a NIH grant – will be presented Tuesday, Sept. 13 in San Francisco at the American Academy of Otolaryngology–Head & Neck Surgery Foundation Annual Meeting.

MiRNA may help cancer researchers unravel the complexities of what happens at the genomic level of cell evolution. It's estimated that there are at least 800 human miRNAs.

Since miRNAs are differentially expressed in various types of cancers compared with noncancerous tissues, researchers believe that they may play a crucial role in the production or formation of tumors.

"By gaining insight into laryngeal cancer, it gives us another level to understand what goes wrong and when cells decide to embark on a tumor genesis journey. From there, it's possible for researchers to look at how to control cancer growth and improve treatment," says co-author Maria J. Worsham, Ph.D., director of research in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

The goal of the Henry Ford study was to discover miRNAs specific to laryngeal squamous cell carcinoma – a form of head and neck cancer that starts in the voice box.

Led by Dr. Chen, the researchers performed global miRNA profiling on stored laryngeal squamous cell carcinoma samples, as well as non-cancerous tissue samples from the larynx.

The team then used quantitative real-time polymerase chain reaction – a fast and inexpensive technique used to copy small segments of DNA – to verify miRNAs in the laryngeal cancer samples.

Of the 800 human miRNAs, 23 were found to be different between the cancerous and normal laryngeal tissue samples.

Among the 23 miRNAs tied to laryngeal cancer through the Henry Ford study, 15 had yet to be reported in head and neck cancer.

With the field narrowed to 23 miRNAs in laryngeal cancer, it presents researchers with the opportunity to quantify each piece of RNA and further study miRNAs in head and neck cancer, notes Dr. Chen.

The NIH-funded head and neck squamous carcinoma cohort for Detroit, with over 1,000 primary patients, includes more than 200 laryngeal sites, giving Henry Ford researchers the opportunity to look at miRNA expression in a larger group of laryngeal cancers as well as in other head and neck cancer sites.

Along with Drs. Chen and Worsham, study co-authors from Henry Ford are Josena K. Stephen, M.D.; Shaleta Havard; Veena Shah, M.D.; Glendon Gardner, M.D.; and Vanessa G. Schweitzer, M.D.

Research Support: NIH grant R01DE15990.

Krista Hopson | EurekAlert!
Further information:
http://www.hfhs.org

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Researchers devise microreactor to study formation of methane hydrate

23.08.2017 | Materials Sciences

ShAPEing the future of magnesium car parts

23.08.2017 | Automotive Engineering

New insights into the world of trypanosomes

23.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>