The role of microRNA (miRNA), the small, non-coding RNA molecules that regulate human genes, has recently come into greater focus as researchers continue to understand the cellular mechanics of cancer development, says Kang Mei Chen, M.D., the study's lead author.
"While they may be small, miRNAs are no longer being viewed as just molecular noise," says Dr. Chen, a research investigator in the Department of Otolaryngology – Head & Neck Surgery at Henry Ford Hospital.
"We now recognize miRNAs as bigger players with increasing prominence in theories about cancer."
Findings from the Henry Ford study – supported by a NIH grant – will be presented Tuesday, Sept. 13 in San Francisco at the American Academy of Otolaryngology–Head & Neck Surgery Foundation Annual Meeting.
MiRNA may help cancer researchers unravel the complexities of what happens at the genomic level of cell evolution. It's estimated that there are at least 800 human miRNAs.
Since miRNAs are differentially expressed in various types of cancers compared with noncancerous tissues, researchers believe that they may play a crucial role in the production or formation of tumors.
"By gaining insight into laryngeal cancer, it gives us another level to understand what goes wrong and when cells decide to embark on a tumor genesis journey. From there, it's possible for researchers to look at how to control cancer growth and improve treatment," says co-author Maria J. Worsham, Ph.D., director of research in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.
The goal of the Henry Ford study was to discover miRNAs specific to laryngeal squamous cell carcinoma – a form of head and neck cancer that starts in the voice box.
Led by Dr. Chen, the researchers performed global miRNA profiling on stored laryngeal squamous cell carcinoma samples, as well as non-cancerous tissue samples from the larynx.
The team then used quantitative real-time polymerase chain reaction – a fast and inexpensive technique used to copy small segments of DNA – to verify miRNAs in the laryngeal cancer samples.
Of the 800 human miRNAs, 23 were found to be different between the cancerous and normal laryngeal tissue samples.
Among the 23 miRNAs tied to laryngeal cancer through the Henry Ford study, 15 had yet to be reported in head and neck cancer.
With the field narrowed to 23 miRNAs in laryngeal cancer, it presents researchers with the opportunity to quantify each piece of RNA and further study miRNAs in head and neck cancer, notes Dr. Chen.
The NIH-funded head and neck squamous carcinoma cohort for Detroit, with over 1,000 primary patients, includes more than 200 laryngeal sites, giving Henry Ford researchers the opportunity to look at miRNA expression in a larger group of laryngeal cancers as well as in other head and neck cancer sites.
Along with Drs. Chen and Worsham, study co-authors from Henry Ford are Josena K. Stephen, M.D.; Shaleta Havard; Veena Shah, M.D.; Glendon Gardner, M.D.; and Vanessa G. Schweitzer, M.D.
Research Support: NIH grant R01DE15990.
Krista Hopson | EurekAlert!
Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center
The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences