Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Harm reduction cigarettes can be more harmful than conventional brands, researchers report

21.10.2010
Prue Talbot's lab at UC Riverside studied the effect of cigarette smoke on human embryonic stem cells

To reduce the toxicity of cigarette smoke, tobacco companies have introduced "harm reduction cigarettes," often marketed as safer than conventional brands.

But stem cell scientists at the University of California, Riverside have found that even sidestream smoke (which burns off the tip of a cigarette) from harm reduction cigarettes impairs growth of human embryonic stem cells more than sidestream smoke from a conventional brand.

"Harm reduction products are not necessarily safer than their conventional counterparts," said Prue Talbot, the director of UC Riverside's Stem Cell Center and the research team leader. "Our analyses show there is significant toxicity in harm reduction products, and our data show that reduction of carcinogens in harm reduction mainstream smoke does not necessarily reduce the toxicity of unfiltered sidestream smoke."

Because it is not possible to directly determine chemical toxicity on actual human embryos, the researchers developed tests with human embryonic stem cells, which model young embryos, to measure and compare the toxicity of mainstream (smoke actively inhaled by smokers) and sidestream smoke from both conventional and harm reduction cigarette brands.

"Embryonic stem cells provide the best model currently available for evaluating the effects of environmental toxicants on prenatal stages of development, which are usually the most sensitive to chemical stress," said Talbot, a professor of cell biology and neuroscience.

Her group also found that sidestream smoke was consistently more potent to the embryonic stem cells than mainstream smoke, regardless of whether the cigarette brand was harm reduction or conventional.

"This information should be valuable to potential users of harm reduction cigarettes and should be taken into account when establishing policies regarding the sale, advertising, and use of harm reduction products," Talbot said.

Study results appear in the November issue of Toxicological Sciences.

For the analyses, the researchers used a rapid human embryonic stem cell-based test that provides data on dynamic cellular processes by combining time-lapse video data with video bioinformatics tools.

Talbot's research team examined the following harm-reduction cigarette brands: Marlboro Lights, Advance Premium Lights, and Quest. The team used Marlboro Red cigarettes to represent conventional brands.

Tobacco smoke is comprised of both mainstream smoke and sidestream smoke. The latter is the major component of secondhand smoke, also called environmental tobacco smoke, and is inhaled by passive smokers.

Harm reduction cigarettes are made using complex filters or by genetically altering tobacco plants to reduce nicotine concentration.

Talbot was joined in the research by UCR's Sabrina Lin, the first author of the research paper, Shawn Fonteno, and Jo-Hao (Nikki) Weng.

The research was funded by a grant from the Tobacco-Related Disease Research Program of the University of California to Talbot; and fellowships to Lin and Fonteno.

The University of California, Riverside (www.ucr.edu) is a doctoral research university, a living laboratory for groundbreaking exploration of issues critical to Inland Southern California, the state and communities around the world. Reflecting California's diverse culture, UCR's enrollment of about 18,000 is expected to grow to 21,000 students by 2020. The campus is planning a medical school and has reached the heart of the Coachella Valley by way of the UCR Palm Desert Graduate Center. The campus has an annual statewide economic impact of more than $1 billion.

A broadcast studio with fiber cable to the AT&T Hollywood hub is available for live or taped interviews. To learn more, call (951) UCR-NEWS.

Iqbal Pittalwala | EurekAlert!
Further information:
http://www.ucr.edu

More articles from Studies and Analyses:

nachricht Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

A whole-body approach to understanding chemosensory cells

13.12.2017 | Health and Medicine

Water without windows: Capturing water vapor inside an electron microscope

13.12.2017 | Physics and Astronomy

Cellular Self-Digestion Process Triggers Autoimmune Disease

13.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>