Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Growth Hormone Treatment Tied to Increased Risk of Stroke

15.08.2014

Children who receive growth hormone treatment to help them grow taller may be at a slightly increased risk of having a stroke as young adults, according to a study published in the August 13, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology. The researchers caution against either initiating or stopping growth hormone treatment without first talking with their doctor.

“We believe the tens of thousands of people worldwide who are treated with growth hormones should be informed about this risk,” said corresponding study author Joël Coste, MD, PhD, of Paris Descartes University and AP-HP in Paris, France. “More research is needed to show whether the growth hormone treatment is the cause of this increased risk, but in the meantime parents and doctors should consider this association as they weigh their options for treatment.” 

The study looked at children who took growth hormone treatment for short stature or growth hormone deficiency with no known cause. The study involved 6,874 people in France who were treated with recombinant growth hormone (not pituitary-derived growth hormone) and were born before 1990 and started treatment between 1985 and 1996.

Researchers then followed up from 2008 to 2010 with health questionnaires and a review of medical records and checked death certificates for the cause of death for any participants who had died. The average time between the start of treatment and the last follow-up was 17 years. Participants were an average age of 11 when they started the growth hormone treatment and took it for an average of 3.9 years. 

During the follow-up period, 11 of the participants had a stroke. Of those, eight people had hemorrhagic strokes, which involve bleeding in or around the brain. The strokes occurred at an average age of 24. Four of the people died as a result of the stroke. 

The rate of stroke in this group was then compared to the rate of stroke in two registries that collect information on strokes occurring in Dijon, France, and Oxford, United Kingdom. Those registries showed that the expected number of strokes in the group would have been between three and seven cases, rather than the 11 that occurred, making the people treated with growth hormone between 50 percent more likely and 3.6 times more likely to have a stroke than people of similar ages in the general population. A registry of children with small stature who were not treated with recombinant growth hormone would have been a better comparison group, but such a registry is not available. 

The results were stronger when looking at just hemorrhagic stroke, where about two cases would have been expected to occur, rather than the eight that did occur, making people treated with growth hormone three to more than four times more likely to have a stroke than those in the general population. 

Because the researchers were not able to collect all possible information on every participant, they used a statistical analysis to account for any stroke cases that were missed. That analysis estimated that an additional five strokes may have been missed in the growth hormone group, and that people taking growth hormone were up to nine times more likely to have a hemorrhagic stroke than those in the general population.  

“There has been a long-running debate about the usefulness, ethics and cost of growth hormone treatment, especially for otherwise healthy children,” said Rebecca N. Ichord, MD, of the Perelman School of Medicine at the University of Pennsylvania in Philadelphia and a member of the American Academy of Neurology, who wrote an editorial accompanying the study.

“These new results will likely intensify the debate. Doctors who prescribe growth hormone treatment will need to discuss this association, consider its strengths and weaknesses and weigh it in their recommendations. And people who have taken the therapy or start it should be informed about the signs of stroke, the importance of seeking treatment quickly and prevention strategies.” 

Coste noted that people who misuse growth hormone treatment to improve athletic performance or body building results should also learn about these findings. 

The study received specific funding from the French Ministry of Health, following funding from the French drug safety agency, the French National Institute of Cancer and Commission of European Communities.  

To learn more about stroke, please visit www.aan.com/patients.  

The American Academy of Neurology, an association of 28,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy. 

For more information about the American Academy of Neurology, visit http://www.aan.com

Rachel L. Seroka | American Academy of Neurology

Further reports about: Neurology Risk Treatment death hemorrhagic hormone recombinant stroke strokes weigh

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The fastest light-driven current source

Controlling electronic current is essential to modern electronics, as data and signals are transferred by streams of electrons which are controlled at high speed. Demands on transmission speeds are also increasing as technology develops. Scientists from the Chair of Laser Physics and the Chair of Applied Physics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in switching on a current with a desired direction in graphene using a single laser pulse within a femtosecond ¬¬ – a femtosecond corresponds to the millionth part of a billionth of a second. This is more than a thousand times faster compared to the most efficient transistors today.

Graphene is up to the job

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Nerves control the body’s bacterial community

26.09.2017 | Life Sciences

Four elements make 2-D optical platform

26.09.2017 | Physics and Astronomy

Goodbye, login. Hello, heart scan

26.09.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>