Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Good News for Parkinson’s Patients: Drugs May Ease Depression without Worsening Motor Problems

12.04.2012
Certain antidepressants appear to decrease depression in people with Parkinson’s disease without worsening motor problems, according to a study published in the April 11, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.

“These results are exciting because depression is common in Parkinson’s but we weren’t sure about the best way to treat it. Older antidepressants are effective but have a lot of side effects.

The newer antidepressants have fewer side effects but we didn’t know if they’d be effective in people with Parkinson’s. We were also worried that they might worsen the motor problems that come with the disease,” said research author Irene H. Richard, MD, of the University of Rochester Medical Center in New York and a member of the American Academy of Neurology.

Parkinson's disease is a chronic neurologic disorder that worsens over time, leaving patients less able to direct or control their movements due to the loss of cells in various parts of the brain. In addition to the physical problems, Parkinson’s can also cause psychological symptoms. Almost one-half of people with Parkinson’s suffer from depression, and it is a major cause of disability.

The drugs tested were paroxetine, which is an antidepressant in the class called selective serotonin reuptake inhibitors (SSRIs), and venlafaxine extended release, which is in the serotonin and norepinephrine reuptake inhibitors (SNRIs) class.

The clinical trial lasted three months and involved 115 people in various stages of Parkinson’s disease who met the criteria for depression. About one-third of the participants received paroxetine, one-third received venlafaxine and one-third received a dummy pill. The dosage of the drug could be increased until the participant’s depression was effectively treated.

On average, the people receiving paroxetine had a 13 point (59 percent) improvement and those receiving venlafaxine had an 11 point (52 percent) improvement in their scores on the Hamilton Rating Scale for Depression. People who received the dummy pill had a 6.8 point (32 percent) improvement. The results, as measured by three other depression rating scales, were similar. “The study suggests that, while there is a clear ‘placebo’ effect, there is a greater benefit from the antidepressant medications,” said Richard.

The drugs were generally well tolerated and did not lead to any worsening in motor functioning.

The study was supported by the National Institutes of Health/National Institute of Neurological Disorders and Stroke and Johns Hopkins University School of Medicine. Wyeth Pharmaceuticals provided venlafaxine XR, while Glaxo-Smith Kline provided paroxetine.

The American Academy of Neurology, an association of 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease and multiple sclerosis.

For more information about the American Academy of Neurology, visit http://www.aan.com

Rachel L. Seroka | American Academy of Neurology
Further information:
http://www.aan.com

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>