Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Genome-wide study identifies 8 new susceptibility loci for atopic dermatitis

Researchers at the RIKEN Center for Genomic Medicine (CGM) and their colleagues have identified 8 new loci associated with susceptibility to atopic dermatitis in the Japanese population. The findings, which appear in the journal Nature Genetics, advance our understanding of the genetic basis of the skin disorder, which affects millions of children and adults around the world.

Atopic dermatitis (often called ecszema) is a chronic, relapsing inflammatory skin condition affecting as much as one-fifth of children and 1-3% of adults in industrialized countries. Those with the condition have skin that reacts easily to the environment and becomes flaky and itchy. While treatment can alleviate some of these symptoms, current techniques remain ineffective in many cases, due in part to a limited scientific understanding of the origins of the condition.

The research group set out to shed light on these origins using a genome-wide association study (GWAS), an approach which identifies gene loci associated with a particular trait. With its strong genetic basis, atopic dermatitis is well suited to the GWAS approach. Three previous GWAS on European and Chinese populations identified 7 loci associated with the condition, but no such studies have been conducted on Japanese people.

To fill this gap, the group conducted a thorough GWAS on 1472 subjects with atopic dermatitis and 7971 controls from among the Japanese population, and then validated their results in a separate study on 1856 subjects with atopic dermatitis and 7021 controls. Analyzing a total of roughly 600,000 genetic variants (called Single Nucleotide Polymorphisms or SNPs), they identified 8 new genetic regions associated with atopic dermatitis and confirmed the 7 loci observed in earlier studies. Among these regions, they identified variants at the IL1RL1/IL18R1/IL18RAP and human leukocyte antigen (HLA) loci, both of which have been associated with bronchial asthma in recent GWAS.

The group's findings thus suggest that atopic dermatitis and asthma have overlapping susceptibility regions, and thus that these regions contain common genetic factors for many allergic diseases. Other loci reveal a wide variety of additional factors possibly involved in the condition, suggesting paths for future research and pointing the way to more effective treatment techniques.


Tomomitsu Hirota, et al. "Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population." Nature Genetics, 2012, DOI: 10.1038/ng.2438


RIKEN is Japan's flagship research institute devoted to basic and applied research. Over 2500 papers by RIKEN researchers are published every year in reputable scientific and technical journals, covering topics ranging across a broad spectrum of disciplines including physics, chemistry, biology, medical science and engineering. RIKEN's advanced research environment and strong emphasis on interdisciplinary collaboration has earned itself an unparalleled reputation for scientific excellence in Japan and around the world.

Reach us on twitter: @rikenresearch

RIKEN Global Relations Office | EurekAlert!
Further information:

More articles from Studies and Analyses:

nachricht Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung

nachricht High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>