A study published in the December issue of The Journal of Nuclear Medicine identified positron emission tomography/computed tomography (PET/CT) scans as a potentially useful tool for predicting local recurrence in lung cancer patients treated with radiofrequency ablation (RFA).
RFA, which uses localized thermal energy to kill cancer cells, is increasingly used as an alternative treatment for patients unable to undergo surgery or other therapies to treat lung cancer.
“This study reinforces the utility of 18F-FDG-PET imaging in cancer detection and follow-up while also providing new insight into factors that can be used for earlier prediction of recurrence after radiofrequency ablation of lung tumors,” said Amit Singnurkar, M.D., FRCPC, assistant professor of radiology and medicine at McMaster University and lead author of the study “18F-FDG PET/CT for the Prediction and Detection of Local Recurrence After Radiofrequency Ablation of Malignant Lung Lesions.” Dr. Singnurkar was previously a nuclear oncology fellow at Memorial Sloan-Kettering Cancer Center, where the majority of the study was conducted.
The five-year study followed 68 patients with 94 pulmonary lesions, including metastases and primary lung cancers. By reviewing 18F-FDG PET/CT scans performed before and after RFA, researchers were able to determine several indicators that could help predict local recurrence.
Among pre-RFA scans, lesion size and type of tumor (primary or metastases) were factors in determining potential for local recurrence. Standardized uptake value (glucose metabolic activity) was also a factor in pre-RFA scans, although not independent of lesion size. PET/CT scans conducted after RFA indicated that 18F-FDG uptake patterns, size of ablation margins and standardized uptake value were parameters that could predict the likelihood of recurrence.
Information gleaned from the pre- and post-PET/CT scans can increase the accuracy of recurrence detection and allow earlier diagnosis. This ultimately can facilitate better management, leading to improved patient outcomes.
“Used correctly, molecular imaging can provide more accurate and earlier results than anatomic imaging alone,” noted Singnurkar. “Molecular imaging has the potential to detect and characterize disease earlier, at a point where it can be more amenable to therapy.”
Lung cancer is the leading cause of cancer death in the United States. According to the National Cancer Institute, more than 200,000 patients will be diagnosed with lung cancer and nearly 160,000 will die from the disease this year. The lungs are also a frequent site for metastases from breast, colorectal, prostate, head and neck, and renal cancers.
Authors of the scientific article, “18F-FDG PET/CT for the Prediction and Detection of Local Recurrence After Radiofrequency Ablation of Malignant Lung Lesions,” include: Amit Singnurkar, Steven M. Larson and Heiko Schröder, Department of Radiology/Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, New York; Stephen B. Solomon, Department of Radiology/Interventional Radiology Service, Memorial Sloan-Kettering Cancer Center, New York, New York; and Mithat Gönen; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.
Please visit the SNM Newsroom to view the PDF of the study. To schedule an interview with the researchers, please contact Susan Martonik at (703) 652-6773 or firstname.lastname@example.org. Current and past issues of The Journal of Nuclear Medicine can be found online at http://jnm.snmjournals.org.About SNM—Advancing Molecular Imaging and Therapy
SNM’s more than 17,000 members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice.
Susan Martonik | EurekAlert!
New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg
Disarray in the brain
18.12.2017 | Universität zu Lübeck
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
17.01.2018 | Ecology, The Environment and Conservation
17.01.2018 | Physics and Astronomy
17.01.2018 | Awards Funding