Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Expanding HIV treatment for discordant couples could significantly reduce global HIV epidemic

19.10.2011
A new study uses a mathematical model to predict the potential impact of expanding treatment to discordant couples on controlling the global HIV epidemic-- in these couples one partner has HIV infection and the other does not.

The research conducted at ICAP at Columbia University's Mailman School of Public Health and the Semel Institute of Neuroscience and Human Behavior at University of California in Los Angeles (UCLA) is the first to predict the effect of the expansion of such treatment in couples on the HIV epidemic in certain African countries.

In "Modeling the Impact on the HIV Epidemic of Treating Discordant Couples with Antiretrovirals to Prevent Transmission," authors Wafaa El-Sadr, MD, MPH, MPA, director of ICAP at the Mailman School, and Brian Coburn, PhD and Sally Blower, PhD at UCLA's Center for Biomedical Modeling, designed a mathematical model that was able to determine the number of infections prevented as a result of treating discordant couples. They used their model to make predictions for Ghana, Lesotho, Malawi and Rwanda. Full study findings were e-published on October 11, 2011 in the Journal, AIDS.

The authors use data for their modeling from a recent clinical study, HPTN 052, that showed that treatment of the HIV infected individuals in couples where the other partner was not HIV infected was successful in reducing transmission by 96 percent. "The findings from the modeling study provide insights into what to expect at a country level of expanding such a prevention strategy", noted Dr. El-Sadr, "Getting information to countries with regards to what they can expect from scale up of treatment for discordant couples on their epidemics is critical to their decision making".

"The most important aspect of our study is that by using a model to scale up the results of a clinical trial, we were able to predict the effectiveness of the intervention in controlling HIV epidemics," said Dr. Coburn. "It was very exciting to find that this couples-based intervention could be extremely effective." Dr. Blower added, "Our findings are very important as they show the intervention may be very successful in certain countries but not in others. This means we can use our model to identify which specific countries should begin to rollout this intervention."

The authors also demonstrate a practical approach for identifying countries where the expansion of HIV treatment in discordant couples is likely to have a strong effect in terms of preventing further spread of HIV. Such information is of great value as policy makers and public health leaders tackle tough decision in terms of determining their HIV control programs.

About ICAP

ICAP at Columbia University's Mailman School of Public Health is a global leader in public health, with a broad portfolio of research, training, health system strengthening, and service delivery programs in the United States and around the world. Founded in 2004, ICAP is committed to addressing critical health issues and to improving lives by improving access to high-quality, equitable, and affordable health services. Working hand-in-hand with in-country partners, ICAP has supported more than 1,200 health facilities across 21 countries. More than one million people have received HIV services through ICAP-supported programs. For more information about ICAP, visit http://www.columbia-icap.org. For information about the Mailman School of Public Health, visit http://www.mailman.columbia.edu

For information about the Semel Institute of Neuroscience and Human Behavior at UCLA, visit http://www.semel.ucla.edu

Stephanie Berger | EurekAlert!
Further information:
http://www.columbia.edu

Further reports about: HIV HIV epidemic Human vaccine ICAP Neuroscience behavior health services public health

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>