In the study, the Icelandic company Decode Genetics together with Helmholtz Zentrum München and a number of other international research institutes performed a genome-wide association scan of more than 50,000 test persons. The researchers found several sequence variants associated with asthma.
“Two of the detected sequence variants are of significance for a biochemical pathway in the interleukin-1 cluster,” explained Dr. Matthias Wjst, who was one of the initiators of the study at the Institute of Inhalation Biology of Helmholtz Zentrum München. This finding confirms the results of a research group at Helmholtz Zentrum München from 2004, which showed that the IL-1 gene cluster is associated with asthma.
“We do not yet know what mechanisms underlie the effect of these sequence variants on the inflammatory cells,” Dr. Wjst said, “but these findings give us new starting points for a better understanding of the various hypotheses of allergic inflammation.”
Allergic and respiratory diseases are among the key research areas of Helmholtz Zentrum München, which is dedicated to disease research at the interface of genetics, lifestyle and environmental influences. The center’s research goal is to elucidate biological mechanisms to achieve a better understanding of the disease process and thus to develop therapies and prevention strategies. Neuherberg, January 8, 2009D. Gudbjartson et al.: Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. DOI 10.1038/ng.323
Michael van den Heuvel | alfa
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy