Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Elevated protein levels in cardiac muscles could predict mortality following angioplasty

13.05.2011
New research shows that elevated levels of cardiac troponin T (cTnT) or I (cTnI) in patients who had angioplasty indicate a higher risk of all-cause mortality and long-term adverse events such as heart attack.

Routine monitoring of these protein levels following nonemergent percutaneous coronary intervention (PCI) could improve long-term outcomes for these patients. Details of the analysis are available online in Catheterization and Cardiovascular Interventions, a peer-reviewed journal of The Society for Cardiovascular Angiography and Interventions (SCAI).

More than one million Americans undergo coronary angioplasty each year to improve blood flow in blocked or narrowed arteries leading to the heart, according to the National Heart, Lung and Blood Institute. In cases where elective PCI was performed medical evidence has found that up to 30% of these patients experience minor elevations in cardiac enzymes, particularly levels of creatine kinase muscle-brain (CK-MB), which are associated with an increase in in-hospital adverse cardiac events. Greater elevations of CK-MB are associated with greater long-term mortality.

Recent studies suggest that elevated levels of cardiac troponins T or I are more specific indicators of cardiac muscle damage than CK-MB. However, conflicting data have been published in medical literature regarding the association between cardiac troponin elevation post-PCI and adverse cardiac events. In the current meta-analysis, Dmitriy Feldman, MD, FSCAI, and colleagues from New York Presbyterian Hospital and Weill Cornell Medical College, assessed the prevalence and mortality risk associated with elevated levels of cTnT or cTnI following elective PCI.

The research team conducted electronic and manual searches of all published studies reporting on the prognostic impact of cTnT or cTnI elevation following elective angioplasty. Twenty-two studies, published between 1998 and 2009, were identified and included 22,353 patients. A meta-analysis—the largest to date—of study findings showed that post-PCI levels of cTnT or cTnI were elevated in 26% and 34% of patients, respectively. The follow-up period of participants in the studies analyzed ranged from 3 to 67 months.

"Our analysis demonstrates that post-procedural elevation of cTnT or cTnI provides long-term prognostic information regarding mortality or myocardial infarction," said Dr. Feldman. Results showed that long-term all-cause mortality in patients with elevated cardiac troponin levels after PCI was 5.8% compared to only 4.4% in patients who did not experience an elevation in the cardiac enzymes. Adverse events (death or heart attack) following elective angioplasty were significantly higher in patients with elevated cTnT or cTnI levels (9.2%) compared to those without cTn elevations (5.3%). "Routine monitoring of peri-procedural cTn levels and more intensive outpatient monitoring and treatment of patients with cTn elevations following elective PCI may help to improve long-term adverse outcomes in these patients," Feldman advised.

This study is published in Catheterization and Cardiovascular Interventions. Media wishing to receive a PDF of the article may contact healthnews@wiley.com.

Full citation: "Prognostic Value of Cardiac Troponin-I or Troponin-T Elevation Following Nonemergent Percutaneous Coronary Intervention: A Meta-analysis." Dmitriy N. Feldman, Luke Kim, A. Garvey Rene, Robert M. Minutello, Geoffrey Bergman and S. Chiu Wong. Catheterization and Cardiovascular Interventions; Published Online: May 13, 2011 (DOI: 10.1002/ccd.22962); Print Issue Date: May 2011. http://doi.wiley.com/10.1022/ccd.22962

Catheterization and Cardiovascular Interventions is the official journal of The Society for Cardiovascular Angiography and Interventions. This international journal covers the broad field of cardiovascular diseases. Subject material includes basic and clinical information that is derived from or related to invasive and interventional coronary or peripheral vascular techniques. The journal focuses on material that will be of immediate practical value to physicians providing patient care in the clinical laboratory setting. To accomplish this, the journal publishes Preliminary Reports and Work In Progress articles that complement the traditional Original Studies, Case Reports, and Comprehensive Reviews. Perspective and insight concerning controversial subjects and evolving technologies are provided regularly through Editorial Commentaries furnished by members of the Editorial Board and other experts. Articles are subject to double-blind peer review and complete editorial evaluation prior to any decision regarding acceptability. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1522-726X.

The Society for Cardiovascular Angiography and Interventions (SCAI) is the primary professional association for invasive and interventional cardiologists, representing over 4,300 physicians in 60 countries. The Society's mission is to promote excellence in invasive and interventional cardiovascular medicine through physician education and representation, its monthly journal Catheterization and Cardiovascular Interventions, and the advancement of quality standards to enhance patient care. For more information, please visit www.scai.org or SCAI's comprehensive patient education website, www.SecondsCount.org.

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

Dawn Peters | EurekAlert!
Further information:
http://www.wiley.com

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>