When mammography yields suspicious findings, physicians often use ultrasound to obtain additional information. However, ultrasound has the potential to result in more biopsies because of its relatively low specificity, or inability to accurately distinguish cancerous lesions from benign ones. Approximately 80 percent of breast lesions biopsied turn out to be benign, according to the American Cancer Society.
"There's a lot of room to improve specificity with ultrasound, and elastography can help us do that," said the study's lead author, Stamatia V. Destounis, M.D., a diagnostic radiologist at Elizabeth Wende Breast Care, a large, community-based breast imaging center in Rochester, N.Y. "It's an easy way to eliminate needle biopsy for something that's probably benign."
Elastography improves ultrasound's specificity by utilizing conventional ultrasound imaging to measure the compressibility and mechanical properties of a lesion. Since cancerous tumors tend to be stiffer than surrounding healthy tissue or cysts, a more compressible lesion on elastography is less likely to be malignant.
"You can perform elastography at the same time as handheld ultrasound and view the images on a split screen, with the two-dimensional ultrasound image on the left and the elastography image on the right," Dr. Destounis said.
As part of the ongoing study, 179 patients underwent breast ultrasound and elastography. The research team obtained 184 elastograms and performed biopsies on all solid lesions. Of 134 biopsies, 56 revealed cancer. Elastography properly identified 98 percent of lesions that had malignant findings on biopsy, and 82 percent of lesions that turned out to be benign. Elastography was also more accurate than ultrasound in gauging the size of the lesions.
"Ultrasound can underestimate the true size of lesions, as it only sees the actual mass and not the surrounding changes the mass may cause," Dr. Destounis said.
In 2009, there will be an estimated 192,370 new cases of invasive breast cancer among women in the United States, according to the American Cancer Society, along with about 62,280 new cases of ductal carcinoma in situ, a noninvasive, early form of breast cancer.
Coauthors are Andrea L. Arieno, B.S., Melissa N. Skolny, M.S., Renee Morgan, R.T., Patricia Somerville, M.D., and Philip F. Murphy, M.D.
Also at RSNA 2009, Dr. Smitha Putturaya, M.D., F.R.C.R., presented findings from an ongoing, seven-year study on breast elastography conducted at the Charing Cross Hospital Breast Unit in London, U.K. Dr. Putturaya and colleagues found that using elastography as an adjunct to routine breast ultrasound safely decreases the number of biopsies of benign lesions and offers the potential to map tumors more precisely.
Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT
Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy