New research shows that children with febrile status epilepticus (FSE) who receive earlier treatment with antiepileptic drugs (AEDs) experience a reduction in the duration of the seizure. The study published in Epilepsia, a journal of the International League Against Epilepsy (ILAE), suggests that a standard Emergency Medical Services (EMS) treatment protocol for FSE is needed in the U.S.
While medical evidence reports that brief or simple febrile seizures are most common, up to 10% of cases are prolonged and meet the criteria for status epilepticus (SE)—a critical condition where a persistent seizure lasts more than 30 minutes. Prior research shows that FSE accounts for 25% of all childhood SE, with more than 70% of SE cases occurring in the second year of life. Prolonged seizures place patients at risk of short-term and long-term complications, including the development of epilepsy.
"The time from the start of the seizure to treatment is crucial to improving patient outcomes," said lead author Syndi Seinfeld, DO, assistant professor, Division of Child Neurology at Children's Hospital of Richmond at Virginia Commonwealth University. "Our study is the first to examine the treatment of FSE by EMS, which currently does not have a standard therapy protocol for prolonged seizures."
The present study recruited 199 pediatric patients who were part of the FEBSTAT study—a prospective, multicenter, NIH-funded study (PI Shlomo Shinnar MD PhD at Albert Einstein College of Medicine) investigating the consequences of FSE. The children, between the ages of 1 month and 6 years, had a seizure or cluster of seizures lasting more than 30 minutes. Researchers analyzed the relationship between seizure duration, treatment delay and related morbidity.
"The FEBSTAT study is designed to understand the consequences of prolonged febrile seizures in hopes of identifying children at greater risk of adverse outcomes and to help develop better treatments," said Brandy Fureman, Ph.D., a program director at the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health.
Findings indicate that roughly 90% (179) of children received at least one AED and more than AED was needed in 70% (140) of patients to terminate FSE. On average it was 30 minutes from the seizure onset to the time EMS or emergency department staff administered the first AED. The mean seizure time was 81 minutes for children treated prior to arrival at the emergency department and 95 minutes for those who were not.
Further analyses determined the average time to end the seizure was 38 minutes following the first AED dose. Seizure duration was 83 minutes in 48% of patients who needed respiratory support and 58 minutes for subjects not requiring respiratory support.
"Our findings clearly show that early AED initiation results in shorter seizure duration," concludes Dr. Seinfeld. "A standard FSE treatment protocol prior to arrival at the hospital, along with training for EMS staff, is needed across the U.S. to help improve outcomes for children with prolonged seizures."
This study is published in Epilepsia. Media wishing to receive a PDF of this article may contact email@example.com.
Full citation: "Emergency Management of Febrile Status Epilepticus: Results of The FEBSTAT Study." Syndi Seinfeld, Shlomo Shinnar, Shumei Sun, Dale C Hesdorffer, Xiaoyan Deng, Ruth C Shinnar, Kathryn O'Hara, Douglas R Nordli Jr, L Matthew Frank, William Gallentine, Solomon L Moshé, John M Pellock and the FEBSTAT study team. Epilepsia; Published Online: February 6, 2014 (DOI: 10.1111/epi.12526).
URL Upon Publication: http://doi.wiley.com/10.1111/epi.12526
Author Contact: Media wishing to speak with Dr. Seinfeld may contact Eric Peters with Virginia Commonwealth University at firstname.lastname@example.org or at 804-828-0563.
About the Journal
Epilepsia is the leading, most authoritative source for current clinical and research results on all aspects of epilepsy. As the journal of the International League Against Epilepsy, subscribers every month will review scientific evidence and clinical methodology in: clinical neurology, neurophysiology, molecular biology, neuroimaging, neurochemistry, neurosurgery, pharmacology, neuroepidemiology, and therapeutic trials. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1528-1167.
About the International League Against Epilepsy
The International League Against Epilepsy (ILAE) is the world's preeminent association of physicians and health professionals working toward a world where no person's life is limited by epilepsy. Since 1909 the ILAE has provided educational and research resources that are essential in understanding, diagnosing and treating persons with epilepsy. The ILAE supports health professionals, patients, and their care providers, governments, and the general public worldwide by advancing knowledge of epilepsy.
Wiley is a global provider of content-enabled solutions that improve outcomes in research, education, and professional practice. Our core businesses produce scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising; professional books, subscription products, certification and training services and online applications; and education content and services including integrated online teaching and learning resources for undergraduate and graduate students and lifelong learners.
Founded in 1807, John Wiley & Sons, Inc. (NYSE: JWa, JWb), has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley and its acquired companies have published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace. Wiley's global headquarters are located in Hoboken, New Jersey, with operations in the U.S., Europe, Asia, Canada, and Australia.
Dawn Peters | EurekAlert!
Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung
High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences