Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early life stress may predict cardiovascular disease

10.02.2010
Early life stress could be a risk factor for cardiovascular disease in adulthood, researchers report.

"We think early life stress increases sensitivity to a hormone known to increase your blood pressure and increases your cardiovascular risk in adult life," said Dr. Jennifer Pollock, biochemist in the Vascular Biology Center at the Medical College of Georgia and corresponding author on the study published online in Hypertension.

The studies in a proven model of chronic behavioral stress – separating rat pups from their mother three hours daily for two weeks – showed no long-term impact on key indicators of cardiovascular disease such as increased blood pressure, heart rate or inflammation in blood vessel walls.

But when the rats reached adulthood, an infusion of the hormone angiotensin II resulted in rapid and dramatic increases in all key indicators in animals that experienced early life stress. Stress activates the renin-angiotensin system which produces angiotensin II and is a major regulator of blood vessel growth and inflammation – both heavily implicated in heart disease. "They cannot adapt to stress as well as a normal animal does," Dr. Pollock said. Within a few days, for example, blood pressure was nearly twice as high in the early-stress animals.

The chronic stress model most typically has been used to look at the psychological impact of childhood stress; this was the first time it was used to measure cardiovascular impact, Dr. Pollock said. Findings correlate with studies published in Circulation in 2004 that identified adverse childhood events, such as abuse or parental loss, in the backgrounds of many adults with ischemic heart disease.

"We want to be able to prevent this long-term consequence," said Dr. Analia S. Loria, MCG postdoctoral fellow and the study's first author. Although the adult rats seemed fine until stressed, the scientists noted the inevitability of stress in life.

Next steps include determining the mechanism that translates early life stress into cardiovascular risk; they suspect it results in genetic alterations at a vulnerable time in development. "Hormones can modulate gene expression and, during stress, you have very high levels of stress hormone," Dr. Loria said.

To further test the findings. they are blocking the angiotensin II receptor in rats to see if that decreases the cardiovascular impact in animals with early life stress. And, to more closely mimic what happens in real life, they are feeding high-fat diets to the rats to see if, like the angiotensin II infusions, it exaggerates cardiovascular disease risk. Receptor blockers are commonly used in cardiovascular patients who have high levels of angiotensin II.

The scientists also will be studying gender differences in response to early life stress since their initial studies were in male rats. Psychological studies indicate that females are less impacted by early life stress and the scientists predict they will find similar results in the cardiovascular response.

The research was funded by the National Institutes of Health and an American Heart Association postdoctoral fellowship.

Toni Baker | EurekAlert!
Further information:
http://www.mcg.edu

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>