Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early heart attack therapy with bone marrow extract improves cardiac function

02.07.2009
A UCSF study for the treatment of heart failure after heart attack found that the extract derived from bone marrow cells is as effective as therapy using bone marrow stem cells for improving cardiac function, decreasing the formation of scar tissue and improving cardiac pumping capacity after heart attack.

Findings were published online and in the July 2009 issue of the Journal of Molecular Therapy. The cover of the journal features a microscope image of cells from the UCSF study.

The studies were done in mice using a novel stem cell delivery method developed by UCSF researchers to show that the extract from bone marrow cells is as beneficial to cardiac function as are intact, whole cells. Both the cell and cell extract therapies resulted in the presence of more blood vessels and less cardiac cell death, or apoptosis, than no therapy. The study also showed that heart function benefitted despite the finding that few of the injected cells remained in the heart at one month after therapy.

"Peer-reviewed medical literature is controversial as to whether bone marrow cells differentiate into cardiomyocytes, or cardiac muscle cells, but there is general agreement that stem cell therapy with these cells results in some level of functional improvement after a heart attack. The exact mechanism for this is not yet clear. Our results confirm that whole cells are not necessarily required in order to see the beneficial effects of bone marrow cell therapy," said Yerem Yeghiazarians, MD, study author, cardiologist and director of UCSF's Translational Cardiac Stem Cell Development Program.

UCSF researchers are investigating these new therapies to improve cardiac function after heart attack in an effort to prevent heart failure. Heart failure occurs when cardiac muscle is damaged and scar tissue replaces beating cardiomyocytes. As scar replaces healthy tissue, it causes the heart to enlarge and lose its pumping capacity. When the pumping capacity decreases, the heart fills with fluid, which moves to the lungs and can lead to organ failure and death.

"Current therapies improve symptoms but do not replace scar tissue. Our hope is to use stem cells to decrease the scar, minimize the loss of cardiac muscle and maintain or even improve the cardiac function after a heart attack," Yeghiazarians said.

Using a novel, closed-chest, ultrasound-guided injection technique developed by Yeghiazarians and his colleagues, the team administered three different groups with bone marrow cells, bone marrow cell extract, or saline (for the control group). The injections were administered at day three after heart attack – a timeframe somewhat similar to human biology on days six-to-seven after heart attack.

The team found at day 28 that both the bone marrow cell group and the extract group had significantly smaller heart damage than the control group.

Left-ventricular ejection fraction (LVEF), or the measurement of blood pumped out of the ventricles per heart beat, fell uniformly in each group after heart attack from a level of about 57.2 percent to 38.4 percent. At day 28 (and after the therapies had been administered on day three), LVEF improved in both the bone marrow cell and extract groups to approximately 40.6 and 39.1 percent as compared to approximately 33.2 percent for the control group.

"We hope our findings can help in the development of new therapies for improving heart function after the deleterious effects of a heart attack," says Yeghiazarians.

The team is continuing to evaluate bone marrow cell and extract therapies in order to identify the proteins and factors within the extract and gain insight into the possible mechanisms of cardiac functional improvement.

"The best acute therapy for a heart attack remains early recognition and revascularization of the blocked artery to minimize the damage to the heart muscle," said Yeghiazarians. "Although the prognosis depends on multiple factors, what we know for sure is that the sooner a heart attack gets diagnosed and cardiologists open the blocked artery, the better the long-term outcome. There are a number of ongoing stem cell-based clinical trials, and depending on further research and the outcome of these studies, we might have new therapies for the treatment of patients who suffer from a heart attack in the not-too-distant future."

Additional authors are Andrew J. Boyle, MD, PhD; Matthew L. Springer, PhD; William Grossman, MD; Yan Zhang, MD, PhD; Richard E. Sievers; Franca S. Angeli, MD; Juha Koskenvuo, MD, PhD; Junya Takagawa, MD, PhD; Mohan N. Viswanathan, MD; Jianqin Ye, MD, PhD; Neel K. Kapasi; Petros Minasi; Rachel Mirsky; Megha Prasad; Shereen A. Saini; Henry Shih; and Maelene L. Wong of UCSF.

The study was supported by the UCSF Cardiac Stem Cell Foundation, UCSF Research Evaluation and Allocation Committee and the Wayne and Gladys Valley Foundation.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. For further information, visit www.ucsf.edu.

Lauren Hammit | EurekAlert!
Further information:
http://www.ucsf.edu

More articles from Studies and Analyses:

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>