Published online Nov. 4, the multi-institutional study strengthens a growing body of research documenting the earlier onset of puberty in girls of all races.
"The impact of earlier maturation in girls has important clinical implications involving psychosocial and biologic outcomes," said Frank Biro, MD, lead investigator and a physician in the Division of Adolescent Medicine at Cincinnati Children's Hospital Medical Center. "The current study suggests clinicians may need to redefine the ages for both early and late maturation in girls."
Girls with earlier maturation are at risk for a multitude of challenges, including lower self-esteem, higher rates of depression, norm-breaking behaviors and lower academic achievement. Early maturation also results in greater risks of obesity, hypertension and several cancers – including breast, ovarian and endometrial cancer.
The study was conducted through the Breast Cancer and Environmental Research Program, established by the National Institute of Environmental Health Science. Pediatrics is the journal of the American Academy of Pediatrics.
Researchers at centers in the San Francisco Bay Area, Cincinnati and New York City examined the ages of 1,239 girls at the onset of breast development and the impact of body mass index and race/ethnicity. The girls ranged in age from 6 to 8 years at enrollment and were followed at regular intervals from 2004 to 2011. Researchers used well-established criteria of pubertal maturation, including the five stages of breast development known as the Tanner Breast Stages.
The girls were followed longitudinally, which involved multiple regular visits for each girl. Researchers said this method provided a good perspective of what happened to each girl and when it occurred.
Researchers found the respective ages at the onset of breast development varied by race, body mass index (obesity), and geographic location. Breast development began in white, non-Hispanic girls, at a median age of 9.7 years, earlier than previously reported. Black girls continue to experience breast development earlier than white girls, at a median age of 8.8 years. The median age for Hispanic girls in the study was 9.3 years, and 9.7 years for Asian girls.
Body mass index was a stronger predictor of earlier puberty than race or ethnicity. Although the research team is still working to confirm the exact environmental and physiological factors behind the phenomenon, they conclude the earlier onset of puberty in white girls is likely caused by greater obesity.
Other institutions collaborating on the study include: Kaiser Permanente Division of Research, Oakland, Calif.; Mount Sinai School of Medicine, New York; California Department of Public Health and the University of California at Berkeley and San Francisco; and the University of Cincinnati College of Medicine.
Funding support for the study came from: the Breast Cancer and the Environment Research Program of the National Institute of Environmental Health Sciences and the National Cancer Institute (grant numbers U01ES012770, U01ES012771, U01ES012800, U01ES012801, U01ES019435, U01ES019453, U01ES019454, U01ES019457), with additional support from the National Institute of Environmental Health Sciences (P01ES009584, P30ES006096); the National Center for Research Resources (UL1RR024131, UL1RR029887, UL1RR026314); the Molecular Epidemiology in Children's Environmental Health training grant (T32-ES10957); and the Avon Foundation.
About Cincinnati Children's:
Cincinnati Children's Hospital Medical Center ranks third in the nation among all Honor Roll hospitals in U.S. News and World Report's 2013 Best Children's Hospitals ranking. It is ranked #1 for cancer and in the top 10 for nine of 10 pediatric specialties. Cincinnati Children's, a non-profit organization, is one of the top three recipients of pediatric research grants from the National Institutes of Health, and a research and teaching affiliate of the University of Cincinnati College of Medicine. The medical center is internationally recognized for improving child health and transforming delivery of care through fully integrated, globally recognized research, education and innovation. Additional information can be found at http://www.cincinnatichildrens.org. Connect on the Cincinnati Children's blog, via Facebook and on Twitter.
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
21.03.2018 | Physics and Astronomy
21.03.2018 | Materials Sciences
21.03.2018 | Life Sciences