Proteins that repair damage to DNA are important for maintaining cells' health, particularly for preventing the accumulation of genetic damage that could increase the chances of becoming cancerous.
Researchers have found that, in the general population, there are variations in the genes that encode these DNA repair proteins. Research has also shown a link between reduced DNA repair and susceptibility to a variety of cancers, including breast, colon, and lung cancer.
To determine the potential role of genetic variants—or polymorphisms—in DNA repair genes in the development of Hodgkin disease, Dr. Randa El-Zein and colleagues at The University of Texas M.D. Anderson Cancer Center in Houston evaluated the relationship between polymorphisms in five DNA repair genes (XPC, XPD, XPG, XRCC1, and XRCC3) in a population of 200 Hodgkin disease patients and 220 healthy individuals.
These five genes are involved in different pathways that repair DNA by performing different modifications to damaged DNA. Changes in these genes can change the make-up and structure of the proteins that carry out these repair processes and therefore could influence how well DNA repair is performed.
The researchers found that variations in DNA repair genes may modify the risk of HD especially when interactions between the pathways are considered. Depending on the variant or combination thereof, people could be, up to four times more likely to develop the disease.
The authors concluded that "these data suggest that genetic polymorphisms in DNA repair genes may modify the risk of Hodgkin disease especially when interactions between the pathways are considered." They added that genetic variants in the different DNA repair pathways should be further evaluated to better understand their role in Hodgkin disease susceptibility in individuals.
David Sampson | EurekAlert!
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Process Engineering
23.01.2017 | Physics and Astronomy
23.01.2017 | Life Sciences