Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New discovery on the causes of contact allergy

11.10.2010
The fragrances used in many household and skincare products can cause contact allergy when exposed to oxygen in the air, reveals research from the University of Gothenburg’s Faculty of Science in conjunction with the University of Gothenburg to be presented at the dermatologist conference in Gothenburg.

The researchers studied how these substances can be activated through contact with oxygen in the air, and how this, in turn, can affect the skin.

One particular study looked at whether the activated fragrances caused contact allergy when tested on eczema patients at Sahlgrenska University Hospital’s Dermatology Clinic and the Occupational and Environmental Dermatology Clinic in Malmö. It was found that a high percentage of the 3,400 eczema patients tested had an allergic reaction to the substances.

“In a bid to gain a deeper understanding of how contact allergy occurs, we are now using state-of-the-art microscopic equipment to follow what happens to an allergen once it gets into the skin,” says Ann-Therese Karlberg, professor of dermatochemistry and skin allergy at the Faculty of Science’s Department of Chemistry, and a researcher at the Sahlgrenska Academy.

When determining how allergenic a substance is, consideration must also be given to the skin’s ability to activate a substance through the metabolism.

“We’ve developed a mixture that reflects the content of real skin enzymes, and use it to investigate whether the chemical substances can be activated in the skin and become allergenic."

Their discovery will help the health service to diagnose allergic contact eczema correctly through the development of new diagnostic tools, and reduce the number of cases of allergic contact eczema in the long term. For patients, the right diagnosis means that they can avoid exposure to substances that trigger the problem, and so give their eczema a chance to heal.

“Future work will see us evaluating new diagnostic methods and carrying out in-depth studies of what goes on in the skin. This will enable us to develop new medicines and replace the only treatment that is currently available for eczema, namely cortisone cream,” explains Karlberg, who believes that their research could improve preventive work through its impact on manufacturers, consumers and legislation.

CONTACT ALLERGY
Contact allergy is estimated to affect nearly 20% of the population in Europe and means that patients develop eczema where they have come into contact with substances they are allergic to. After nickel, fragrances are the most common cause of contact allergy. This type of allergy cannot be cured, but is alleviated with cortisone cream, and all contact with the allergen should be avoided.
For more information, please contact: Ann-Therese Karlberg, professor of dermatochemistry and skin allergy at the Department of Chemistry and coordinator for the Centre for Skin Research at the University of Gothenburg (SkinResGU).
tel. +46 31 786 91 09
e-mail: karlberg@chem.gu.se

Helena Aaberg | idw
Further information:
http://www.gu.se

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>