The study shows that for patients with uterine cancer not receiving chemotherapy, tumors were more likely to return if radiation therapy was delayed nine weeks or longer following surgery, with only 43 percent having relapse-free survival after five years.
By comparison, patients starting radiation treatment soon after surgery had a five-year relapse-free survival of 90 percent.
"Our data suggests that a shorter interval of time between hysterectomy and start of radiation treatment may be beneficial for patients," says lead author Mohamed Elshaikh, M.D., senior staff physician in the Department of Radiation Oncology at Henry Ford Hospital.
Study results will be presented Monday, October 30 at the 54th Annual Meeting of the American Society for Radiation Oncology (ASTRO) in Boston.
Endometrial cancers mainly arise from the tissue lining the uterus. They are the most common gynecologic cancers in the US, with more than 43,000 women diagnosed and an estimated 7,950 dying from the disease in 2010, according to the National Cancer Institute.
A total hysterectomy (surgical removal of the uterus) is the most common approach for treatment of endometrial cancers.
To assess the impact of time between hysterectomy and the start of radiation treatment on tumor recurrence, Dr. Elshaikh and his colleagues conducted a retrospective study of patients who underwent surgery for uterine cancer between 1988 and 2010.
Of the 1,450 Henry Ford patients reviewed with stage I-III uterine cancer, 308 received radiation therapy without chemotherapy after hysterectomy with at least one year follow-up. The median age for patients was 65 and the median follow-up was six years.
About 75 percent of the study group started radiation therapy less than nine weeks after surgery, while the others began treatment nine weeks or more after surgery.
Among the study group, there were 43 cases where the cancer returned. Tumor recurrence was significantly associated with treatment delay of nine weeks or longer.
Along with Dr. Elshaikh, Henry Ford study co-authors are Richard Cattaneo II, M.D.; Gordon Jacobsen, MS; and Rabbie Hanna, M.D.
Research support: Henry Ford Hospital
Krista Hopson | EurekAlert!
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
Urbanization to convert 300,000 km2 of prime croplands
27.12.2016 | Mercator Research Institute on Global Commons and Climate Change (MCC) gGmbH
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Power and Electrical Engineering
16.01.2017 | Information Technology
16.01.2017 | Power and Electrical Engineering