Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

CU team finds likely culprit behind liver problems linked to intravenous feeding

10.10.2013
Researchers know that feeding some patients intravenously can save their lives – but also can cause liver damage. Now scientists at the University of Colorado and Children's Hospital Colorado have figured out the likely culprit, one of the ingredients in intravenous food, behind the liver problems.

The discovery, published Oct. 9 in Science Translational Medicine, could point the way to better treatments for patients who are medically vulnerable and, often, very young.

"We still have more to learn about the optimal mix of lipids for intravenous nutrition," said Ron Sokol, part of the research team. "Our hope is that this study will lead us to intravenous nutrition that results in less stress on the liver."

A life-saving option for some patients with intestinal problems or pancreatitis is to provide food intravenously. But this option, usually used for patients who can't tolerate or absorb food from their intestines, is associated with liver damage while helping in other ways.

The risk is especially high for premature infants and children with intestinal failure or short bowel syndrome, who often depend on intravenous feeding – or Parenteral nutrition (PN) -- for years. The longer a patient is on PN and the more severe their intestinal problems, the greater the risk of what is called PN-associated liver disease (PNALD).

Clinical evidence had suggested that lipids derived from soy might be part of the problem. The researchers, also representing University of Cincinnati, Cincinnati Children's Hospital and Emory University, zeroed in on the soy factor.

They found that one derivative of soy – called stigmasterol – appeared to prevent the flow of bile from the liver in experimental mice. They also figured out the chemical mechanism behind that problem, and found that microbes in the gut appeared to contribute to PNALD as well.

"The results of this study may help promote a shift away from solutions containing stigmasterol for patients dependent on intravenous nutrition," Sokol said.

Dan Meyers | EurekAlert!
Further information:
http://www.ucdenver.edu

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

Im Focus: Artificial Enzymes for Hydrogen Conversion

Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.

Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

New quantum phenomena in graphene superlattices

19.09.2017 | Physics and Astronomy

A simple additive to improve film quality

19.09.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>