The study appeared on-line in the journal Alcoholism: Clinical and Experimental Research. The study is the first to identify a mechanism underlying one of the main behavioral differences between adolescents and adults in their response to alcohol.
“This study is a significant advancement in understanding why adolescents are insensitive to alcohol and provides some insights into why teens might consequently consume alcohol to dangerous levels,” said Dr. Doug Matthews, a research scientist at Baylor who led the study. “This differential effect is not due to different blood-alcohol levels. Such reduced sensitivity in teens is troublesome considering that binge and heavy alcohol consumption increases throughout human adolescence and peaks at 21 to 25 years of age. Therefore understanding the mechanisms that underlie the reduced sensitivity to alcohol during adolescence is critical.”
Specifically, the Baylor researchers found the firing rate of a particular neuron called the cerebellar Purkinje neuron was insensitive to large alcohol doses in adolescent animal models, while the firing rate of those neurons was significantly depressed in adults. The spontaneous firing rate in adults from Purkinje neurons decreased approximately 20 percent, which researchers said indicates potential motor impairment. Adolescents, on the other hand, did show a slight motor impairment, however the firing rates from adolescent Purkinje neurons did not dramatically change in response to alcohol, and in fact showed a five percent increase in firing rate.
The Baylor researchers said this alcohol-induced reduction of spontaneous Purkinje neuron firing rates in adults could explain the greater sensitivity to alcohol’s motor impairing effects in adults compared to adolescents. However, there are likely to be contributions from other systems involved to cause thee different behavioral effects.
For more information, contact Matt Pene, assistant director of media communications at Baylor, at (254) 710-4656.
Matt Pene | Newswise Science News
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
Urbanization to convert 300,000 km2 of prime croplands
27.12.2016 | Mercator Research Institute on Global Commons and Climate Change (MCC) gGmbH
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
18.01.2017 | Power and Electrical Engineering
18.01.2017 | Materials Sciences
18.01.2017 | Life Sciences